Journal ArticleDOI
N-Heterocyclic Carbene Catalyzed Intramolecular Hydroacylation of Activated Alkynes: Synthesis of Chromones
TLDR
In this article, an organocatalytic intramolecular Stetter-type hydroacylation reaction between an aldehyde and an activated alkyne has been developed, which induces salicylaldehyde-derived alkynes derivatives to assemble into a series of chromone derivatives using a catalytic amount of thiazolium-based carbene catalyst.Abstract:
An organocatalytic intramolecular Stetter-type hydroacylation reaction between an aldehyde and an activated alkyne has been developed. This study induces salicylaldehyde-derived alkyne derivatives to assemble into a series of chromone derivatives using a catalytic amount of thiazolium-based carbene catalyst.read more
Citations
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Journal ArticleDOI
Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes.
Journal ArticleDOI
Chromone: A Valid Scaffold in Medicinal Chemistry
Alexandra Gaspar,Alexandra Gaspar,Maria João Matos,Maria João Matos,Jorge Garrido,Jorge Garrido,Eugenio Uriarte,Fernanda Borges +7 more
TL;DR: This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013) and SFRH/BD/61262/2009.
Journal ArticleDOI
Enantioselective N-heterocyclic carbene-catalyzed Michael addition to α,β-unsaturated aldehydes by redox oxidation.
TL;DR: Enantioselective N-heterocyclic carbene-catalyzed Michael addition reactions to α,β-unsaturated aldehydes by redox oxidation led to 3,4-dihydro-α-pyrones in good yields and excellent ee's.
Journal ArticleDOI
A Family of Thiazolium Salt Derived N‐Heterocyclic Carbenes (NHCs) for Organocatalysis: Synthesis, Investigation and Application in Cross‐Benzoin Condensation
TL;DR: In this paper, a family of thiazolium salt derived N-heterocyclic carbenes bearing sterically demanding aryl substituents on the nitrogen and with varying backbone substitution patterns have been synthesized.
Journal ArticleDOI
Ferrocene and Triazole-Appended Rhodamine Based Multisignaling Sensors for Hg2+ and Their Application in Live Cell Imaging
TL;DR: In this article, two triazole-appended ferrocene-rhodamine conjugates, C47H45N7O3Fe (2) and C49H49N 7O 3Fe (3), have been synthesized, and their electrochemical, optical, and metal cation sensing properties have been explored in aqueous medium.
References
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A stable crystalline carbene
TL;DR: Synthese, structure et caracterisation du (1,3-bis [1-adamantyl]-2, 3-dihydro)-2,carbenoimidazole prepare par deprotonation du chlorure de (1 3-bis] [1]- imidazolium as discussed by the authors.
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Organocatalysis by N-Heterocyclic Carbenes
TL;DR: The inversion of the classical reactivity (Umpolung) opens up new synthetic pathways in biochemical processes as nucleophilic acylations and in nature, the coenzyme thiamine (vitamin B1), a natural thiazolium salt, utilizes a catalytic variant of this concept in biochemical process as nucleophile acylation.
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Ruthenium-based heterocyclic carbene-coordinated olefin metathesis catalysts.
TL;DR: The fascinating story of olefin (or alkene) metathesis began almost five decades ago, when Anderson and Merckling reported the first carbon-carbon double-bond rearrangement reaction in the titanium-catalyzed polymerization of norbornene.
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N-Heterocyclic Carbenes†‡
TL;DR: The chemistry of N-heterocyclic carbenes has long been limited to metal coordination compounds derived from azolium precursors, a development that was started by Ofele and Wanzlick in 1968 as discussed by the authors.