Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs
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TLDR
For oral administration, many publications reported useful advantages of nanocrystals to improve in vivo performances i.e. pharmacokinetics, pharmacodynamics, safety and tar- geted delivery which were discussed in this review.About:
This article is published in Asian Journal of Pharmaceutical Sciences.The article was published on 2015-02-01 and is currently open access. It has received 323 citations till now.read more
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Journal ArticleDOI
Nano based drug delivery systems: recent developments and future prospects
Jayanta Kumar Patra,Gitishree Das,Leonardo Fernandes Fraceto,Leonardo Fernandes Fraceto,Estefania Vangelie Ramos Campos,Estefania Vangelie Ramos Campos,Maria del Pilar Rodriguez-Torres,Laura Susana Acosta-Torres,Luis A. Diaz-Torres,Renato Grillo,Mallappa Kumara Swamy,Shivesh Sharma,Solomon Habtemariam,Han-Seung Shin +13 more
TL;DR: An updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs and selective diagnosis through disease marker molecules is presented.
Journal ArticleDOI
Therapeutic Nanoparticles and Their Targeted Delivery Applications.
TL;DR: Understanding of the characteristics of nanoparticles and their interactions with the biological environment will enable us to establish novel strategies for the treatment, prevention, and diagnosis in many diseases, particularly untreatable ones.
Book ChapterDOI
Multifunctional nanocrystals for cancer therapy: a potential nanocarrier
Emil Joseph,Gautam Singhvi +1 more
TL;DR: This review gives an overview of recent advances and current status of nanocrystals, especially with respect to the method of preparations, physicochemical characterizations, in vitro/in vivo performance, scale-up techniques and applications in the field of drug delivery for different tumor targeting.
Journal ArticleDOI
Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals - A comprehensive review.
Luis Padrela,Miguel Rodrigues,Andreia Duarte,Ana M.A. Dias,Mara E.M. Braga,Hermínio C. de Sousa +5 more
TL;DR: A comprehensive state‐of‐the‐art review on scCO2‐based processes focused on the formation and on the control of the physicochemical, structural and morphological properties of amorphous/crystalline pure drug nanoparticles.
Journal ArticleDOI
Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability
TL;DR: The present work provides an overview of the achievements in improving the bioavailability of poorly soluble drugs according to their administration route, describes the methods developed to overcome physicochemical and stability-related problems, and reviews different stabilizers and surface agents that are able to modify the drug delivery and targeting.
References
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Journal ArticleDOI
Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation
TL;DR: The physical background of the diminution process, effects of production parameters (power density, number of homogenisation cycles) on crystal size, clinical batch production and scaling up of the production are presented.
Journal ArticleDOI
Nanosizing--oral formulation development and biopharmaceutical evaluation.
TL;DR: The principles behind nanosizing, the production and characterization of nanoformulations as well as the current experience with utilization of such formulations in vivo are described.
Journal ArticleDOI
Nanocrystal technology, drug delivery and clinical applications
TL;DR: The physics behind the drug nanocrystals and changes of their physical properties are discussed, and the special physical effects of nanocry crystals explained which are utilized in each market product.
Journal ArticleDOI
Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs
Gary Liversidge,Kenneth C. Cundy +1 more
TL;DR: In this paper, a randomized crossover study was conducted in fasted male beagle dogs to compare absolute oral bioavailability of danazol from three formulations, i.e., an aqueous dispersion of nanoparticulate Danazol (mean particle size 169 nm), B, danazOL-hydroxypropyl-β-cyclodextrin (HPB) complex, C, an aiquous suspension of conventional DanazOL particles (means particle size 10 μm).
Journal ArticleDOI
Top-Down Production of Drug Nanocrystals - Nanosuspension Stabilization, Miniaturization and Transformation Into Solid Products
TL;DR: This mini-review focuses on recent advances with respect to three topics considering drug nanocrystals, focussing on the maintenance of the preservation of the rapid dissolution properties of the nanocry crystals after further downstream processing.