Open AccessJournal Article
Natural history of the major histocompatibility complex
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This article is published in American Journal of Human Genetics.The article was published on 1987-05-01 and is currently open access. It has received 662 citations till now.read more
Citations
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Journal ArticleDOI
Slipped-strand mispairing: a major mechanism for DNA sequence evolution.
G Levinson,George A. Gutman +1 more
TL;DR: Evidence is presented that single-base repeats (the shortest possible motifs) are represented by longer runs in mammalian introns than would be expected on a random basis, supporting the idea that SSM may be a ubiquitous force in the evolution of the eukaryotic genome.
Journal ArticleDOI
Gene map of the extended human MHC
Roger Horton,Laurens G. Wilming,Vikki Rand,Ruth C. Lovering,Elspeth A. Bruford,Varsha K. Khodiyar,Michael J. Lush,Sue Povey,C. Conover Talbot,Mathew W. Wright,H Wain,John Trowsdale,Andreas Ziegler,Stephan Beck +13 more
TL;DR: A gene map of the xMHC is presented and its content in relation to paralogy, polymorphism, immune function and disease is reviewed.
Journal ArticleDOI
Genetic compatibility, mate choice and patterns of parentage: invited review.
TL;DR: There is growing interest in the possibility that genetic compatibility may drive mate choice, including gamete choice, particularly from the perspective of understanding why females frequently mate with more than one male, and whether there is any evidence for mate choice driven by these factors.
Journal ArticleDOI
MHC studies in nonmodel vertebrates: what have we learned about natural selection in 15 years?
TL;DR: Overall, the evidence is compelling that the MHC currently represents the best system available in vertebrates to investigate how natural selection can promote local adaptation at the gene level despite the counteracting actions of migration and genetic drift.
Journal ArticleDOI
The importance of immune gene variability (MHC) in evolutionary ecology and conservation
TL;DR: Empirical support for the functional importance of MHC variability in parasite resistance is summarised with emphasis on the evidence derived from free-ranging animal populations investigated in their natural habitat.
References
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Journal ArticleDOI
Slipped-strand mispairing: a major mechanism for DNA sequence evolution.
G Levinson,George A. Gutman +1 more
TL;DR: Evidence is presented that single-base repeats (the shortest possible motifs) are represented by longer runs in mammalian introns than would be expected on a random basis, supporting the idea that SSM may be a ubiquitous force in the evolution of the eukaryotic genome.
Journal ArticleDOI
Gene map of the extended human MHC
Roger Horton,Laurens G. Wilming,Vikki Rand,Ruth C. Lovering,Elspeth A. Bruford,Varsha K. Khodiyar,Michael J. Lush,Sue Povey,C. Conover Talbot,Mathew W. Wright,H Wain,John Trowsdale,Andreas Ziegler,Stephan Beck +13 more
TL;DR: A gene map of the xMHC is presented and its content in relation to paralogy, polymorphism, immune function and disease is reviewed.
Journal ArticleDOI
Genetic compatibility, mate choice and patterns of parentage: invited review.
TL;DR: There is growing interest in the possibility that genetic compatibility may drive mate choice, including gamete choice, particularly from the perspective of understanding why females frequently mate with more than one male, and whether there is any evidence for mate choice driven by these factors.
Journal ArticleDOI
MHC studies in nonmodel vertebrates: what have we learned about natural selection in 15 years?
TL;DR: Overall, the evidence is compelling that the MHC currently represents the best system available in vertebrates to investigate how natural selection can promote local adaptation at the gene level despite the counteracting actions of migration and genetic drift.
Journal ArticleDOI
The importance of immune gene variability (MHC) in evolutionary ecology and conservation
TL;DR: Empirical support for the functional importance of MHC variability in parasite resistance is summarised with emphasis on the evidence derived from free-ranging animal populations investigated in their natural habitat.