Roger Horton

TL;DR: Analysis of six annotation categories showed that evolutionarily conserved regions are the predominant sites for differential DNA methylation and that a core region surrounding the transcriptional start site is an informative surrogate for promoter methylation.

TL;DR: A gene map of the xMHC is presented and its content in relation to paralogy, polymorphism, immune function and disease is reviewed.

TL;DR: Analysis of the sequence reveals many intra- and interchromosomal duplications, including segmental duplications adjacent to both the centromere and the large heterochromatic block, and detects recently duplicated genes that exhibit different rates of sequence divergence, presumably reflecting natural selection.

TL;DR: The MHC Haplotype Project was to provide a comprehensively annotated reference sequence of a single, human leukocyte antigen-homozygous MHC haplotype and to use it as a basis against which variations could be assessed from seven other similarly homozygous cell lines, representative of the most common MHChaplotype in the European population.

TL;DR: This paper reported 4.75 Mb of contiguous sequence for each of two common haplotypes of the major histocompatibility complex (MHC) to which susceptibility to >100 diseases has been mapped.