Journal ArticleDOI
Naturstoffchemie 110. Mitt.†: Synthese des 1-Hydroxy-7-methoxyacridons aus Boenninghausenia albiflora REICHB. (Rutaceae); Darstellung einiger einfacher Hydroxy-, Methoxy- und Nitroacridone‡ §
Johannes Reisch,Wiltrud Probst +1 more
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In this paper, the acridone 5 was prepared by a modified Ullmann synthesis and the structure of the alkaloid 1-hydroxy-7methoxyacridone from Boenninghausenia albiflora was confirmed by way of synthesis.Abstract:
Uber eine modifizierte Ullmann-Synthese wurden die Acridone 5 dargestellt. Die 1-Hydroxy-7-methoxyacridon-Struktur fur ein Alkaloid aus Boenninghausenia albiflora REICHB. konnte durch Synthese bestatigt werden.
Natural Product Chemistry, Part 1101): Synthesis of 1-Hydroxy-7-methoxyacridone from Boenninghausenia albiflora REICHB. (Rutaceae). Preparation of Simple Hydroxy-, Methoxy- and Nitroacridones
The acridone 5 was prepared by a modified Ullmann synthesis. The structure of the alkaloid 1-Hydroxy-7-methoxyacridone from Boenninghausenia albiflora REICHB. was confirmed by way of synthesis.read more
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Convenient access to substituted acridines by a Buchwald–Hartwig amination
TL;DR: In this paper, a high yield procedure for the synthesis of anthranilic acids carrying a variety of different substituents as well as their straightforward transformation into the corresponding 9-chloroacridines could be established by using modified Buchwald-Hartwig amination conditions.
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Structure-activity relationship studies of acridones as potential antipsoriatic agents. 2. Synthesis and antiproliferative activity of 10-substituted hydroxy-10H-acridin-9-ones against human keratinocyte growth.
TL;DR: A series of 10-substituted hydroxy-10H-acridin-9-ones were synthesized and studied as potential antipsoriatic agents and Benzyl substitution at the 10-position yielded keratinocyte growth inhibitory activity in the low micromolar range.
Journal ArticleDOI
Synthese und cytostatische Wirkungen des 10‐ und 11‐Nitronoracronycins, Molekülvariationen des cytostatisch wirksamen Acronycins1)
Johannes Reisch,Peter Dziemba +1 more
TL;DR: In this paper, the synthesis and cytotoxicity of 11-and 10-nitronoracronycine from 1.3-dihydroxy-10-methyl-5-nitroacridinone or 1,3-dimethoxy-10methyl-6-nitroid-6.
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Synthese und cytostatische Wirkung des 9-Nitronoracronycins
Johannes Reisch,Wiltrude Probst +1 more
TL;DR: The synthesis of 9-nitronoracronycine from 1,3-dihydroxy-10-methyl-7-nitroacridone (4) and 2-chlor-2.methyl-3-butyne is reported in this paper.
References
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Acetylenchemie. 4 mitt. Synthese von haplophyllin und N-methylflindersin, zwei wege zu N-funktio-nalisierten pyrano[3,2-c]chinolin-alkaloiden†‡
TL;DR: Pyrano[3,2-c]chinolin-Alkaloide (3), geeignete Vorstufen fur photobiomimetische Dimerisierungen, sind durch PTC-Reaktion eines 4-Hydroxychinolin, 2-ons (1) with 3-Chlor-3-methylbut-1-in zuganglich, wobei als Nebenprodukt die Furo[3 2-c]-chinolin 2-on-isomere (5) anfall
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Synthesis of acronycine isosters
TL;DR: In this article, the synthesis of acronycine isosteres is described, and the two key intermediates 6,8-dihydroxy-10-methylbenzo[b][1,8]naphthyridin-5(10H)-one (4b) and 6, 8-Dihydrox-5H-[1]benzopyrano[2,3-b]pyride-5-one (5,1]-pyridine-1.
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The co-occurrence of rutacridone and noracronycine in the roots of Boenninghausenia albiflora
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Die Nitrierung des N‐Methyl‐acridons und die Herstellung des 2.7‐Diamino‐10‐methyl‐acridiniumchlorids (VII. Mitteil. über Acridin)
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13C-NMR-Spektren einiger Acridon-Derivate [1] / 13C NMR Spectra of Some Acridone Derivatives [1]
TL;DR: In this paper, the 13C NMR spectra of acridone derivatives 3-5, 8-12, melicopicine (14), melicopidine (15), and melicopsine (16) are presented.