Journal ArticleDOI
Nephrotoxicity Induced by Cancer Chemotherapy With Special Emphasis on Cisplatin Toxicity
Fernand Ries,Jean Klastersky +1 more
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TLDR
Cisplatin nephrotoxicity is clearly dose-related and used to be considered dose limiting; hyperhydration with mannitol-induced saline diuresis may allow administration of high doses and thus circumvent the dose-limiting effect of cisplatin-induced renal toxicity.About:
This article is published in American Journal of Kidney Diseases.The article was published on 1986-11-01. It has received 292 citations till now. The article focuses on the topics: Nephrotoxicity & Renal magnesium wasting.read more
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Journal ArticleDOI
Mechanisms of Cisplatin nephrotoxicity.
TL;DR: Recent advances in understanding of cisplatin nephrotoxicity are summarized and it is discussed how these advances might lead to more effective prevention.
Journal ArticleDOI
Randomized, Double-Blind Study of Denosumab Versus Zoledronic Acid in the Treatment of Bone Metastases in Patients With Advanced Cancer (Excluding Breast and Prostate Cancer) or Multiple Myeloma
David H. Henry,Luis Costa,François Goldwasser,Vera Hirsh,Vania Hungria,Jana Prausova,Giorgio V. Scagliotti,Harm Sleeboom,Andrew Spencer,Saroj Vadhan-Raj,Roger von Moos,Wolfgang Willenbacher,Penella J. Woll,Jianming Wang,Qi Jiang,Susie Jun,Roger Dansey,Howard S. Yeh +17 more
TL;DR: Denosumab was noninferior (trending to superiority) to ZA in preventing or delaying first on-study SRE in patients with advanced cancer metastatic to bone or myeloma and represents a potential novel treatment option with the convenience of subcutaneous administration and no requirement for renal monitoring or dose adjustment.
Journal ArticleDOI
TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity
TL;DR: The results indicate cisplatin nephrotoxicity is characterized by activation of proinflammatory cytokines and chemokines and TNF-alpha appears to play a central role in the activation of this cytokine response and also in the pathogenesis of cisPlatin renal injury.
Journal ArticleDOI
Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab
David L. Lacey,William J. Boyle,W. Scott Simonet,Paul J. Kostenuik,William C. Dougall,John K. Sullivan,Javier San Martin,Roger Dansey +7 more
TL;DR: This Review chronicles the events that led to an increased understanding of bone resorption, the elucidation of the signalling pathway mediated by osteoprotegerin, receptor activator of NF-κB and RANK ligand (RANKL) and its role in osteoclast biology, as well as the evolution of recombinant RankL antagonists, which culminated in the development of the therapeutic RANKL-targeted antibody denosumab.
Journal ArticleDOI
Cisplatin: a review of toxicities and therapeutic applications.
TL;DR: Cisplatin is a platinum chemotherapeutic used in a variety of malignancies and has shown activity against osteosarcoma, transitional cell carcinomas, squamous cell carcinoma (SCC), melanoma, mesothelioma, carcinomatosis and germinal cell tumours in the dog and in the cat.
References
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Journal ArticleDOI
Platinum Compounds: a New Class of Potent Antitumour Agents
TL;DR: The platinum compounds inhibit sarcoma 180 and leukaemia L1210 in mice and reversibly inhibit cell division in Gram-negative rods1–4.
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Cis-Diamminedichloroplatinum, Vinblastine, and Bleomycin Combination Chemotherapy in Disseminated Testicular Cancer
TL;DR: In this paper, a three-drug combination consisting of cis-diamminedichloroplatinum, vinblastine, and bleomycin was used to treat 50 patients with disseminated testicular cancer.
Milestone in Urology Cis-Diamminedichloroplatinum, Vinblastine, and Bleomycin Combination Chemotherapy in Disseminated Testicular Cancer
TL;DR: Fifty patients with disseminated testicular cancer were treated with a three-drug combination consisting of cis-diamminedichloroplatinum, vinblastine, and bleomycin, producing an overall 85% disease-free status.
Journal ArticleDOI
Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features.
TL;DR: Hematologic data showed derangements associated with intravascular coagulation, the most prominent of which were hypofibrinogenemia and thrombocytopenia, and abnormalities included prolonged prothrombin time, increased fibr inogen-fibrin degradation products, decreased levels of factors V and VIII, cryofibrInogenemia, and microangiopathic hemolytic anemia.
Journal ArticleDOI
High dose cis-platinum diammine dichloride: amelioration of renal toxicity by mannitol diuresis.
Daniel M. Hayes,Esteban Cvitkovic,Robert B. Golbey,Ellen Scheiner,Lawrence Helson,Irwin H. Krakoff +5 more
TL;DR: A clinical trial was undertaken to improve the therapeutic index of cis‐plati‐num diammine dichloride with a concomitantly administered mannitol induced diuresis and CPDD administration, with Clinically significant responses in epidermoid carcinoma of the head and neck, adenocarcinomas of the ovary, and germ cell tumors of the testis.
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