Neurodegenerative disease: A proteostatic boost.
TLDR
Promoting mitochondrial proteostasis counteracts Aβ aggregation in worms and an Alzheimer disease mouse model and links to a mitochondrial stress response that may be conserved across species.Abstract:
Amyloid-β (Aβ)-induced proteotoxicity is linked to a mitochondrial stress response that may be conserved across species, and promoting mitochondrial proteostasis counteracts Aβ aggregation in worms and an Alzheimer disease mouse model.read more
Citations
More filters
Journal ArticleDOI
Microglial priming of antigen presentation and adaptive stimulation in Alzheimer’s disease
TL;DR: The change in functionality of microglia from innate to adaptive immune response in the context of neuroprotection, which may help in the search of novel immune therapy in AD is focused on.
Journal ArticleDOI
Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia
Rashmi Das,Rashmi Das,Abhishek Ankur Balmik,Abhishek Ankur Balmik,Subashchandrabose Chinnathambi,Subashchandrabose Chinnathambi +5 more
TL;DR: It is suggested that microglia modified actin cytoskeleton for phagocytosis and rapid clearance of Tau oligomers in Alzheimer’s disease condition and the peri-membrane polymerization of actin filament and co-localization of Iba1 relate to the microglial movements forPhagocyTosis.
Journal ArticleDOI
Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation.
Cindy Juliet Cristancho Ortiz,Matheus de Freitas Silva,Letizia Pruccoli,Nathalia Fonseca Nadur,Luciana Luiza de Azevedo,Arthur Eugen Kümmerle,Isabella A. Guedes,Laurent E. Dardenne,Luiz Felipe Leomil Coelho,Marcos Jorge R. Guimarães,F. R. D. da Silva,Newton G. Castro,Vanessa Silva Gontijo,Viviana Carolina Trujillo Rojas,Merelym Ketterym de Oliveira,Fabiana C. Vilela,Alexandre Giusti-Paiva,Gisele Maria Barbosa,Lídia Moreira Lima,G. Pinheiro,Letícia Veras,Márcia Renata Mortari,Andrea Tarozzi,Claudio Viegas +23 more
TL;DR: Biological data suggest that compound 3g can treat the inflammatory process and oxidative stress resulting from the overexpression of iNOS and therefore the increase in reactive nitrogen species, and regulate the release of pro-inflammatory cytokines such as IL-1β.
References
More filters
Journal ArticleDOI
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
Vincenzo Sorrentino,Mario Romani,Laurent Mouchiroud,John S. Beck,Hongbo Zhang,Davide D'Amico,Norman Moullan,Francesca Potenza,Adrien W. Schmid,Solène Rietsch,Scott E. Counts,Johan Auwerx +11 more
TL;DR: Evidence of a conserved mitochondrial stress response signature present in diseases involving amyloid-β proteotoxicity in human, mouse and Caenorhabditis elegans that involves the mitochondrial unfolded protein response and mitophagy pathways is provided.