H
Hongbo Zhang
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 32
Citations - 3873
Hongbo Zhang is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Biology & Skeletal muscle. The author has an hindex of 15, co-authored 24 publications receiving 2430 citations. Previous affiliations of Hongbo Zhang include Sun Yat-sen University & University of Zurich.
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Journal ArticleDOI
NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
Hongbo Zhang,Dongryeol Ryu,Yibo Wu,Karim Gariani,Xu Wang,Peiling Luan,Davide D'Amico,Eduardo R. Ropelle,Eduardo R. Ropelle,Matthias P. Lutolf,Ruedi Aebersold,Ruedi Aebersold,Kristina Schoonjans,Keir J. Menzies,Keir J. Menzies,Johan Auwerx +15 more
TL;DR: It is demonstrated the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD+) and its effect on mitochondrial activity as a pivotal switch to modulate muscle SC (MuSC) senescence and it is demonstrated that NR delays senescences of neural SCs and melanocyteSCs and increases mouse life span.
Journal ArticleDOI
Cells of the adult human heart.
Monika Litviňuková,Monika Litviňuková,Carlos Talavera-López,Carlos Talavera-López,Henrike Maatz,Daniel Reichart,Daniel Reichart,Catherine L. Worth,Eric L. Lindberg,Masatoshi Kanda,Masatoshi Kanda,Krzysztof Polanski,Matthias Heinig,Michael Lee,Emily R. Nadelmann,Kenny Roberts,Liz Tuck,Eirini S. Fasouli,Daniel M. DeLaughter,Barbara McDonough,Barbara McDonough,Barbara McDonough,Hiroko Wakimoto,Joshua M. Gorham,Sara Samari,Krishnaa T. Mahbubani,Kourosh Saeb-Parsy,Giannino Patone,Joseph J. Boyle,Hongbo Zhang,Hongbo Zhang,Hao Zhang,Anissa Viveiros,Gavin Y. Oudit,Omer Ali Bayraktar,Jonathan G. Seidman,Christine E. Seidman,Christine E. Seidman,Christine E. Seidman,Michela Noseda,Michela Noseda,Norbert Hubner,Sarah A. Teichmann,Sarah A. Teichmann +43 more
TL;DR: The state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes are used to construct a cellular atlas of the human heart that will aid further research into cardiac physiology and disease and provides a valuable reference for future studies.
Journal ArticleDOI
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
Vincenzo Sorrentino,Mario Romani,Laurent Mouchiroud,John S. Beck,Hongbo Zhang,Davide D'Amico,Norman Moullan,Francesca Potenza,Adrien W. Schmid,Solène Rietsch,Scott E. Counts,Johan Auwerx +11 more
TL;DR: Evidence of a conserved mitochondrial stress response signature present in diseases involving amyloid-β proteotoxicity in human, mouse and Caenorhabditis elegans that involves the mitochondrial unfolded protein response and mitophagy pathways is provided.
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Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice
Karim Gariani,Keir J. Menzies,Dongryeol Ryu,Casey J. Wegner,Xu Wang,Eduardo R. Ropelle,Norman Moullan,Hongbo Zhang,Alessia Perino,Vera Lemos,Bohkyung Kim,Young-Ki Park,Alessandra Piersigilli,Tho X. Pham,Yue Yang,Chai Siah Ku,Sung I. Koo,Anna Fomitchova,Carlos Cantó,Kristina Schoonjans,Anthony A. Sauve,Ji-Young Lee,Johan Auwerx +22 more
TL;DR: It is demonstrated that NR prevents and reverts NAFLD by inducing a sirtuin (SIRT)1‐ and SIRT3‐dependent mitochondrial unfolded protein response, triggering an adaptive mitohormetic pathway to increase hepatic β‐oxidation and mitochondrial complex content and activity.
Journal ArticleDOI
Protein acetylation in metabolism - metabolites and cofactors
TL;DR: The role of reversible acetylation in metabolic control and how changes in levels of metabolites or cofactors directly alter KAT or KDAC activity to link energy status to adaptive cellular and organismal homeostasis are examined.