Journal ArticleDOI
Neurofunctional mechanisms in autism.
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TLDR
This model proposes that complex human behaviors may be guided by multiple overlapping neural mechanisms.Abstract:
Behavioral impairments in autism are theorized to result from abnormal neuronal organization in brain development generating 4 systemically related neurofunctional impairments: (a) canalesthesia, wherein abnormal hippocampal system function "canalizes" sensory records, disrupting integration of information; (b) impaired assignment of the affective significance of stimuli, wherein abnormal amygdaloid system function disrupts affect association; (c) asociality, wherein impaired oxytocin system function flattens social bonding and affiliativeness; and (d) extended selective attention, wherein abnormal organization of temporal and parietal polysensory regions yields aberrant overprocessing of primary representations. This model proposes that complex human behaviors may be guided by multiple overlapping neural mechanisms.read more
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Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Journal ArticleDOI
Visual fixation patterns during viewing of naturalistic social situations as predictors of social competence in individuals with autism.
TL;DR: A novel method of quantifying atypical strategies of social monitoring in a setting that simulates the demands of daily experience is reported, finding that fixation times on mouths and objects but not on eyes are strong predictors of degree of social competence.
Journal ArticleDOI
The Modified Checklist for Autism in Toddlers: an initial study investigating the early detection of autism and pervasive developmental disorders.
TL;DR: Six items pertaining to social relatedness and communication were found to have the best discriminability between children diagnosed with and without autism/PDD.
Journal ArticleDOI
Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder.
TL;DR: A developmental model of risk, risk processes, symptom emergence, and adaptation in ASD is described that offers a framework for understanding early brain plasticity in ASD and its role in prevention of the disorder.
Journal ArticleDOI
A neurobehavioral model of affiliative bonding: Implications for conceptualizing a human trait of affiliation.
TL;DR: It is proposed that the capacity to experience affiliative reward via opiate functioning has a disproportionate weight in determining individual differences in affiliation.
References
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Book
Principles of Neural Science
TL;DR: The principles of neural science as mentioned in this paper have been used in neural networks for the purpose of neural network engineering and neural networks have been applied in the field of neural networks, such as:
Journal ArticleDOI
Diagnostic and Statistical Manual of Mental Disorders, 3rd ed
Arnold M. Cooper,Robert Michels +1 more
Journal ArticleDOI
Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.