Journal ArticleDOI
Neuromuscular block in insects caused by the venom of the digger wasp Philanthus triangulum F.
T. Piek,P. Mantel,E. Engels +2 more
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TLDR
The venom of Philanthus triangulum F. blocks the excitatory and inhibitory neuromuscular transmission, with a concurrent decrease in size of the excited and inhibited post-synaptic potentials, leading to the conclusion that the venom presynaptically inhibits the release of transmitter substances, possibly in a relatively aspecific manner.About:
This article is published in Comparative and General Pharmacology.The article was published on 1971-09-01. It has received 57 citations till now. The article focuses on the topics: Neuromuscular transmission & Excitatory postsynaptic potential.read more
Citations
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Structure and synthesis of a potent glutamate receptor antagonist in wasp venom
Amira T. Eldefrawi,Mohyee E. Eldefrawi,K. Konno,Nabil A. Mansour,Koji Nakanishi,Eugene M. Oltz,Peter N.R. Usherwood +6 more
TL;DR: This philanthotoxin 433 (PTX-433) has been purified, chemically characterized, and subsequently synthesized along with two closely related analogues, which are useful for studying, labeling, and purifying glutamate receptors and may become models for an additional class of therapeutic drugs and possibly insecticides.
Journal ArticleDOI
Manipulation of host behavior by parasitic insects and insect parasites.
TL;DR: This work focuses on recent advances in the study of behavioral manipulation via modulation of the host central nervous system, and describes how a worm may influence the nervous system of its cricket host and manipulate the cricket into committing suicide by jumping into water.
Journal ArticleDOI
Postsynaptic block of a glutamatergic synapse by low molecular weight fractions of spider venom.
TL;DR: Fractions of low molecular weight isolated from the venoms of the New-World spiders, Argiope trifasciata and Araneus gemma block transmission at glutamatergic nerve-muscle junctions in the locust, Schistocerca gregaria indicate uncompetitive antagonism of the glutamate receptor channel complex through open channel block.
Journal ArticleDOI
Block of locust muscle glutamate receptors by δ-philathotoxin occurs after receptor activations
R.B. Clark,P.L. Donaldson,K.A.F. Gration,J. J. Lambert,T. Piek,R. L. Ramsey,W. Spanjer,P.N.R. Usherwood +7 more
TL;DR: It is proposed that the toxin blocks open channels gated by both junctional and extrajunctional glutamate receptors on locust muscle and that δ-PTX enters a compartment of the muscle through the glutamate open channels and that it can also block the open channels from this site.
References
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Journal ArticleDOI
Spontaneous subthreshold activity at motor nerve endings
P. Fatt,Bernard Katz +1 more
TL;DR: The present study arose from the chance observation that end-plates of resting muscle fibres are the seat of spontaneous electric discharges which have the character of miniature end-plate potentials.
Journal ArticleDOI
Peripheral inhibition in skeletal muscle of insects.
Journal ArticleDOI
Structure and Physiology of a Chordotonal Organ in the Locust Leg
TL;DR: The structural and physiological properties of a chordotonal organ found in the metathoracic femoral segments of the locust and grasshopper are described and leg reflexes involving the femoral chordotonals organ and femoral muscles appear to play a very significant role during postural and walking activity.
Journal ArticleDOI
The anatomy and innervation of locust skeletal muscle.
TL;DR: The details of the innervation of a skeletal muscle (extensor tibialis of the metathoracic leg) of the locust Locusta migratoria migratorioides R. & F. are described.
Journal ArticleDOI
Chemical Transmission at the Insect Excitatory Neuromuscular Synapse
P. N. R. Usherwood,P. Machili +1 more
TL;DR: The effects of this substance on the electrical and mechanical properties of a locust neuromuscular preparation are examined to determine the site of action of glutamic acid.
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Effects and Chemical Characterization of Some Paralysing Venoms of Solitary Wasps
T. Piek,W. Spanjer +1 more