Neuroprotective effect of safranal, an active ingredient of Crocus sativus , in a rat model of transient cerebral ischemia.
TLDR
It is concluded that safranal had protective effects on ischemic reperfusion injury in the rat model of stroke by suppressing the production of free radicals and increasing antioxidant activity.Abstract:
Safranal is a monoterpene aldehyde found in saffron (Crocus sativus L.) petals. It has been previously reported that safranal has a wide range of activities such as antioxidant and anti-inflammatory effects. In this study, we examined the effect of safranal on brain injuries in a transient model of focal cerebral ischemia. Transient focal cerebral ischemia was induced by middle cerebral artery occlusion for 30 min, followed by 24 h of reperfusion. Safranal in the doses of 72.5 and 145 mg/kg was administered intraperitoneally at 0, 3, and 6 h after reperfusion. Neurobehavioral deficit, infarct volume, hippocampal cell loss and markers of oxidative stress including thiobarbituric acid reactive substances (TBARS), total sulfhydryl (SH) content, and antioxidant capacity (using FRAP assay) were also assessed. The focal cerebral ischemia induced a significant increase in the neurological score, infarct volume and neuronal cell loss in the ipsilateral hippocampal CA1 and CA3 subfields (p < 0.001) and also oxidative stress markers (p < 0.01). Following safranal administration, the total SH content and antioxidant capacity significantly increased, while marked decreases were observed in the neurological score, infarct volume and hippocampal cell loss, as well as TBARS level. This study concluded that safranal had protective effects on ischemic reperfusion injury in the rat model of stroke. Such effects of safranal may have been exerted mainly by suppressing the production of free radicals and increasing antioxidant activity.read more
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Immunoregulatory and anti-inflammatory properties of Crocus sativus (Saffron) and its main active constituents: A review
Majid Zeinali,Mohammad Reza Zirak,Seyed Abdolrahim Rezaee,Gholamreza Karimi,Hossein Hosseinzadeh +4 more
TL;DR: The main bioactive constituents of saffron may have health-promoting with important benefits in immune-related disorders and can affect both cellular and humoral immunity functions.
Journal ArticleDOI
Saffron bioactives crocin, crocetin and safranal: effect on oxidative stress and mechanisms of action.
TL;DR: The main chemical components responsible for these properties are crocin, crocetin and safranal as mentioned in this paper, which have been shown to have a wide spectrum of biological activities including several properties as antigenotoxic, antioxidant, anticancer, anti-inflammatory, antiatherosclerotic, antidiabetic, hypotensive, hypoglycemic, antihyperlipidemic, antidegenerative and antidepressant.
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Medicinal herbs in the treatment of neuropathic pain: a review.
TL;DR: An extensive review about herbal drugs and plants that exhibited protective effects on neuropathy pain suggests that some herbal plants can be suitable candidates for the treatment of neuropathic pain.
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Neuroprotective Phytochemicals in Experimental Ischemic Stroke: Mechanisms and Potential Clinical Applications
TL;DR: In this article, the authors summarize the research works that report the neuroprotective activity of phytochemicals in the past 10 years and discuss the neuro-protective mechanisms and potential clinical applications of 148 phytochemical compounds that belong to the categories of flavonoids, stilbenoids, other phenols, terpenoids, and alkaloids.
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Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats.
Mohammad Bagher Khorrami,Hamid Reza Sadeghnia,Alireza Pasdar,Alireza Pasdar,Majid Ghayour-Mobarhan,Bamdad Riahi-Zanjani,Alireza Hashemzadeh,Mohammad Hosein Zare,Majid Darroudi +8 more
TL;DR: The results of this study showed that CNPs caused no significant changes in the activity of liver enzymes, hepatic and renal histopathology and hematological parameters, while significantly improved serum redox status.
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TL;DR: It is concluded that aqueous and ethanolic extracts of saffron stigma and petal have an antinociceptive effect, as well as acute and/or chronic anti-inflammatory activity.