Journal ArticleDOI
New cytotoxic metabolites from a deep-sea-derived fungus, Phialocephala sp., strain FL30r.
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TLDR
Two new sorbicillinoids, 1 and 2, together with a novel benzofuranone derivative named phialofurone (3), were isolated from a deep‐sea sediment‐derived fungus, Phialocephala sp, on the basis of spectroscopic data.Abstract:
Two new sorbicillinoids, 1 and 2, together with a novel benzofuranone derivative named phialofurone (3), were isolated from a deep-sea sediment-derived fungus, Phialocephala sp. Their structures were established on the basis of spectroscopic data. All compounds displayed cytotoxic effects against P388 (IC(50) values of 11.5±1.4, 0.1±0.1, and 0.2±0.01 μM, resp.) and K562 (IC(50) values of 22.9±0.8, 4.8±0.3 and 22.4±0.9 μM, resp.) cell lines.read more
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Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
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Fungal natural products in research and development
Anja Schueffler,Timm Anke +1 more
TL;DR: It is concluded that fungi continue to be a rich source of new metabolites and new developments in the uses or the biological activity of known compounds or new derivatives are discussed.
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Recent advances in deep-sea natural products
Danielle Skropeta,Liangqian Wei +1 more
TL;DR: Most strikingly, 75% of the compounds were reported to possess bioactivity, with almost half exhibiting low micromolar cytotoxicity towards a range of human cancer cell lines, along with a significant increase in the number of microbial deep-sea natural products reported.
Journal ArticleDOI
Cold-water marine natural products, 2006 to 2016
TL;DR: Emphasis is given to the biological activities as well as the spectroscopic methods used for the structure elucidation of the new metabolites isolated from cold-water habitats.
Journal ArticleDOI
Sorbicillinoids from Fungi and Their Bioactivities
Jiajia Meng,Xiaohan Wang,Dan Xu,Xiaoxiang Fu,Xuping Zhang,Daowan Lai,Ligang Zhou,Guozhen Zhang +7 more
TL;DR: This mini-review aims to briefly summarize the occurrence, structures, and biological activities of sorbicillinoids.
References
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Journal ArticleDOI
Deep-sea natural products
TL;DR: This review covers the 390 novel marine natural products described to date from deep-water (>50 m) marine fauna, with details on the source organism, its depth and country of origin, along with any reported biological activity of the metabolites.
Journal ArticleDOI
Trisorbicillinone A, a novel sorbicillin trimer, from a deep sea fungus, Phialocephala sp. FL30r
TL;DR: In this article, a trisorbicillin trimer was isolated from a deep sea fungus, Phialocephala sp. FL30r and the structure and relative stereochemistry of 1 were determined based on spectroscopic methods.
Journal ArticleDOI
Two new bisorbicillinoids isolated from a deep-sea fungus, Phialocephala sp. FL30r.
Dehai Li,Fengping Wang,Shengxin Cai,Shengxin Cai,Xiang Zeng,Xiang Xiao,Qianqun Gu,Qianqun Gu,Weiming Zhu,Weiming Zhu +9 more
TL;DR: Two new bisorbicillinoids were isolated from a deep-sea fungus and their structures established using spectroscopic methods, determined by their biosynthesis route and analysis of the CD spectrum.
Journal ArticleDOI
Novel fungal metabolites, demethylsorbicillin and oxosorbicillinol, isolated from Trichoderma sp. USF-2690.
TL;DR: The structures of these compounds, determined from spectroscopic evidence, suggest the possibility that methylation at C-5, C-6, and C-1 of sorbicillin were controlled in the early polyketide stage before the formation of oxidized sorBicillin dimers.