Showing papers in "Natural Product Reports in 2008"

TL;DR: This review describes more than 600 new examples of naturally occurring flavonoids found either as aglycones or glycosides, comprising flavones, flavonols, chalcones, dihydrochalcones and anthocyanidins.

TL;DR: This updated review deals with sample preparation and purification, recent extraction techniques used for natural product separation, liquid-solid and liquid-liquid isolation techniques, as well as multi-step chromatographic operations.

TL;DR: The majority of secondary lichen products are aromatic polyketides, and a number of them has been shown to exhibit marked biological activity.

TL;DR: This review covers the structures, proposed biosynthetic pathways, total synthesis and biological activities of these and other triterpenoids from the plants of the family Schisandraceae.

TL;DR: The present stage of knowledge on structure, biochemical composition, and mechanisms of biosilica formation is reported, focusing particularly on sponges because of the enormous (nano)biotechnological potential of the enzymes involved in this process.

TL;DR: This review describes how the structures of natural products have provided an insipration for new synthetic methodology which yields libraries of diverse bioactive compounds.

TL;DR: An application of the self-organizing map technique is presented for natural product-derived compound and library design and compares properties and pharmacophoric features of drugs and natural products.

TL;DR: The literature survey includes purely synthetic Guanidine derivatives, guanidine alkaloids and non-ribosomal peptides from bacteria and cyanobacteria, as well as related compounds isolated from marine and terrestrial invertebrates and higher plants.

TL;DR: This comprehensive review describes the current status and knowledge of biochemical and molecular processes involved in allyl/propenyl phenol, lignan, norlignan and lignin biosynthesis, and discusses the evidence for non-random macromolecularlignin assembly.

TL;DR: This review covers the 390 novel marine natural products described to date from deep-water (>50 m) marine fauna, with details on the source organism, its depth and country of origin, along with any reported biological activity of the metabolites.

TL;DR: This review surveys efforts to reconstitute key steps in polyketide and nonribosomal peptide biosynthetic pathways with purified enzymes and substrates with purified substrates.

TL;DR: It is proposed that heme attachment influences both heme reduction potential and ligand-iron interactions, which is expected to be similar to heme b.

TL;DR: An overview of the chemistry and biology of the diterpene natural products known as the furanocembranoids, pseudopteranes, and gersolanes is provided.

TL;DR: This article reviews the distribution of tropones and tropolones, the biosynthetic pathways for their production and their biological activities, and there are 154 references.

TL;DR: This review covers progress that has so far been made in terms of its distribution, biosynthesis and metabolic functions, as well as chemical syntheses of mycothiol and alternative substrates and inhibitors of myCothiol biosynthetic and my cothiol-dependent enzymes.

TL;DR: This new semi-synthetic approach exploits the ability of biological systems to efficiently generate complex chiral molecules and of synthetic chemistry to elaborate these into new, or difficult to source, molecules.

TL;DR: The genus Olea contains the economically important European olive tree (Olea europaea L.) and this species is also of chemotaxonomic interest because of the presence of various phenol-conjugated oleosidic secoiridoids or oleOSides.

TL;DR: This review describes the epidermal and glandular chemistry of nonavian reptiles in relation to proposed functions, and includes more than 170 references.

TL;DR: A new polyketide alkylation pathway was characterized that allows access to "beta-branched" structures and its parallels to isoprenoid biosynthesis from primary metabolism and the scope of structures accessible via this pathway are described.

TL;DR: Mycolactone structural variants, produced by Mycobacterium ulcerans and related mycobacteria, are caused by rearrangements among the highly homologous domains and modules within the MlsB polyketide megasynthase, that alter the immunosuppressive and cytotoxic potency of these natural products.

TL;DR: This review details the synthetic studies on this fascinating natural product starting from early studies on the original structure, through the synthesis of the originally proposed structure and the subsequent structural revision, to the eventual successful syntheses of the natural product itself.

TL;DR: Recent advances in the metabolic engineering of microbes for isoprenoid production as well as some novel approaches to gene discovery and expression are reviewed.

TL;DR: This review highlights some of the most elegant and instructive biomimetic syntheses of natural products over the last few years, providing an updated overview of this area of research.

TL;DR: This review describes the efforts to develop convergent strategies for the synthesis of polycyclic ethers and their application to the total synthesis of gambierol, gymnocin-A, and brevenal, and to the partial synthesis of the central part of ciguatoxins and the nonacyclic polyether skeleton of gamieric acids.

TL;DR: This comprehensive review chronicles the synthetic endeavours undertaken over the last 15 years towards the development and realization of practical chemical syntheses of discodermolide and, more recently, dictyostatin, focusing on the methods and strategies employed for achieving overall stereocontrol and key fragment unions, as well as the design and synthesis of novel hybrid structures.

TL;DR: In this article, metal-catalysed homogeneous transformations involving N-heterocyclic carbene (NHC) are described, and the focus of the paper is transition-metal mediated catalysis.

TL;DR: A review of the isolation, biological activity and synthesis of pyranonaphthoquinones and closely related compounds is provided.

TL;DR: An overview on recently developed methods for the stereochemical determination of complex polyketides is given and NMR-spectroscopic, computational, biosynthetic and synthetic methods are discussed.

TL;DR: Synthetic studies on the new DNA-alkylating natural product yatakemycin have served to reassign its structure, assign the absolute stereochemistry, and provide access to yatakmycin and a series of structural analogues for biological evaluation.

TL;DR: Combined quantum mechanics/molecular mechanics (QM/MM) methods are outlined and some recent applications illustrate how calculations of this type can be used to interpret and complement experiments, with important potential implications for practical developments such as drug and catalyst design.