Journal ArticleDOI
New synthesis of 2-nitroimidazoles
Reads0
Chats0
TLDR
In this article, 1-triphenylmethylimidazoles are treated with n-butyllithium in tetrahydrofuran at 0° to form the 2-lithio derivatives.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 1982-03-01. It has received 37 citations till now. The article focuses on the topics: Hydroxymethyl & Yield (chemistry).read more
Citations
More filters
Journal ArticleDOI
Nonpeptide Angiotensin II Receptor Antagonists: Synthesis, Biological Activities, and Structure−Activity Relationships of Imidazole-5-carboxylic Acids Bearing Alkyl, Alkenyl, and Hydroxyalkyl Substituents at the 4-Position and Their Related Compounds
Hiroaki Yanagisawa,Yoshiya Amemiya,Takuro Kanazaki,Yasuo Shimoji,Fujimoto Koichi,Yoshiko Kitahara,Toshio Sada,Makoto Mizuno,Masahiro Ikeda,Shuichi Miyamoto,Youji Furukawa,Hiroyuki Koike +11 more
TL;DR: A series of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds were prepared and evaluated for their antagonistic activities to the angiotensin II (AII) receptor.
Journal ArticleDOI
New Arylthioindoles and Related Bioisosteres at the Sulfur Bridging Group. 4. Synthesis, Tubulin Polymerization, Cell Growth Inhibition, and Molecular Modeling Studies
Giuseppe La Regina,Taradas Sarkar,Ruoli Bai,Michael C. Edler,Roberto Saletti,Antonio Coluccia,Francesco Piscitelli,Lara Minelli,Valerio Gatti,Carmela Mazzoccoli,Vanessa Palermo,Cristina Mazzoni,Claudio Falcone,Anna Ivana Scovassi,Vincenzo Giansanti,Pietro Campiglia,Amalia Porta,Bruno Maresca,Ernest Hamel,Andrea Brancale,Ettore Novellino,Romano Silvestri +21 more
TL;DR: New arylthioindoles along with the corresponding ketone and methylene compounds were potent tubulin assembly inhibitors of MCF-7 cells, and sulfur derivatives were superior or sometimes equivalent to the ketones, while methylene derivatives were substantially less effective.
Journal ArticleDOI
A Convenient Synthesis of Perfluoroalkylated and Fluorinated-Aryl Nitrogen Bases by Electrochemically Induced SRN1 Substitution
TL;DR: Aromatic nucleophilic substitution of some fluorinated aryl halides was also investigated and it was found that 1-iodo-2-(trifluoromethyl)benzene could react successfully under redox-catalyzed conditions with imidazole, 2-(4‘-methoxyphenyl)imidazoles anion, and uracil anion to give the corresponding 5-(fluorinated-aryl) nitrogen bases.
Journal Article
Effect of inhibitor depletion on inhibitory potency: tight binding inhibition of CYP3A by clotrimazole.
TL;DR: It is concluded that microsomal inhibitory potency can be affected by incubation conditions that deplete the unbound concentration of inhibitor available to the enzyme.
References
More filters
Journal ArticleDOI
Differentiation of 1,4- and 1,5-disubstituted imidazoles
Journal ArticleDOI
Studies on Imidazoles. II. The Synthesis of 5-Imidazolecarboxylates from Glycine and Substituted Glycine Esters
Journal ArticleDOI
The pKa Values of Some 2-Aminomidazolium Ions
Journal ArticleDOI
Sulphydryls, ascorbate and oxygen as modifiers of the toxicity and metabolism of misonidazole in vitro.
Y C Taylor,A M Rauth +1 more
TL;DR: Both toxicity and drug metabolism could be immediately halted by introducing O2 during hypoxic exposure to MISO and the roles which sulphydryls and O2 may play are discussed in terms of a possible model for the metabolism-mediated toxicity of MISO.