A
Amalia Porta
Researcher at University of Salerno
Publications - 79
Citations - 2335
Amalia Porta is an academic researcher from University of Salerno. The author has contributed to research in topics: Gene & Candida albicans. The author has an hindex of 26, co-authored 74 publications receiving 1962 citations. Previous affiliations of Amalia Porta include International Institute of Minnesota & University of Washington.
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Journal ArticleDOI
Effect of environmental pH on morphological development of Candida albicans is mediated via the PacC-related transcription factor encoded by PRR2
TL;DR: The results demonstrate that the pH response pathway of Aspergillus is conserved and that this pathway has been adapted to control dimorphism in C. albicans.
Journal ArticleDOI
Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications☆ , ☆☆
Zsolt Török,Tim Crul,Bruno Maresca,Gerhard J. Schütz,Félix Viana,Laura Dindia,Stefano Piotto,Mario Brameshuber,Gábor Balogh,Mária Péter,Amalia Porta,Alfonso Trapani,Imre Gombos,Attila Glatz,Burcin Gungor,Begüm Peksel,László Vígh,Bálint Csoboz,Ibolya Horváth,Mathilakath M. Vijayan,Phillip L. Hooper,John L. Harwood +21 more
TL;DR: The classic heat shock (stress) response (HSR) was originally attributed to protein denaturation, but it is observed that a deregulated HSR is found in a large number of important diseases where more detailed knowledge of the molecular mechanisms involved may offer timely opportunities for clinical interventions and new, innovative drug treatments.
Journal ArticleDOI
PRR1, a homolog of Aspergillus nidulans palF, controls pH-dependent gene expression and filamentation in Candida albicans.
TL;DR: It is concluded that PRR1 encodes a component of the pH-dependent response pathway in C. albicans and that this pathway regulates the expression of multiple components of hyphal development.
Journal ArticleDOI
Dominant active alleles of RIM101 (PRR2) bypass the pH restriction on filamentation of Candida albicans.
Abdelmalic El Barkani,Oliver Kurzai,William A. Fonzi,Ana M. Ramon,Amalia Porta,Amalia Porta,Matthias Frosch,Fritz A. Mühlschlegel +7 more
TL;DR: RIM101 is suggested to be responsible for the pH dependence of hyphal development of Candida albicans.
Journal ArticleDOI
Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors
Giuseppe La Regina,Ruoli Bai,Whilelmina Maria Rensen,Erica Di Cesare,Antonio Coluccia,Francesco Piscitelli,Valeria Famiglini,Alessia Reggio,Marianna Nalli,Sveva Pelliccia,Eleonora Da Pozzo,Barbara Costa,Ilaria Granata,Amalia Porta,Bruno Maresca,Alessandra Soriani,Maria Luisa Iannitto,Angela Santoni,Junjie Li,Marlein Miranda Cona,Feng Chen,Yicheng Ni,Andrea Brancale,Giulio Dondio,Stefania Vultaggio,Mario Varasi,Ciro Mercurio,Claudia Martini,Ernest Hamel,Patrizia Lavia,Ettore Novellino,Romano Silvestri +31 more
TL;DR: New arylthioindole derivatives having different cyclic substituents at position 2 of the indole were synthesized as anticancer agents that were notably more potent than vinorelbine, vinblastine, and paclitaxel in the NCI/ADR-RES and Messa/Dx5 cell lines, which overexpress P-glycoprotein.