Nonsense-mediated mRNA decay in mammals.
TLDR
Nonsense-mediated mRNA decay in mammalian cells generally degrades mRNAs that terminate translation more than 50-55 nucleotides upstream of a splicing-generated exon-exon junction.Abstract:
Nonsense-mediated mRNA decay (NMD) in mammalian cells generally degrades mRNAs that terminate translation more than 50-55 nucleotides upstream of a splicing-generated exon-exon junction (reviewed in [Maquat, 2004a][1]; [Nagy and Maquat, 1998][2]). Notably, dependence on exon-exon junctionsread more
Citations
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Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay
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References
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Journal ArticleDOI
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics
TL;DR: The acquisition and loss of mRNA-associated proteins accompanies the transition from the pioneer round to subsequent rounds of translation, and from translational competence to substrate for nonsense-mediated mRNA decay.
Journal ArticleDOI
A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance
Eszter Nagy,Lynne E. Maquat +1 more
TL;DR: This paper aims to explore the role of language and time in the development of romantic attachment and its role in the story of Henry IV.
Journal ArticleDOI
The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions
TL;DR: It is reported that the spliceosome stably deposits several proteins on mRNAs, probably as a single complex of ∼335 kDa, which protects 8 nucleotides of mRNA from complete RNase digestion at a conserved position 20–24 nucleotide upstream of exon–exon junctions.
Journal ArticleDOI
Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise.
TL;DR: Novel results document that nonsense surveillance is a crucial post-transcriptional regulatory event that influences the expression of broad classes of physiologic transcripts, has been functionally incorporated into essential homeostatic mechanisms and suppresses expression of evolutionary remnants.
Journal ArticleDOI
The exon–exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay
TL;DR: The composition of the exon–exon junction complex is dynamic in vivo and is subject to significant evolution upon mRNA export to the cytoplasm.
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