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Normal and tumor-derived myoepithelial cells differ in their ability to interact withluminal breast epithelial cells for polarity and basement membrane deposition
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Gudjonsson et al. as discussed by the authors showed that normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition.Abstract:
Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition Thorarinn Gudjonsson 1 , Lone Ronnov-Jessen 2 , Rene Villadsen1, Fritz Rank 3 , Mina J. Bissell 4 and Ole William Petersen 1,* Structural Cell Biology Unit, Institute of Medical Anatomy, The Panum Institute, DK-2200 Copenhagen N, Denmark Zoophysiological Laboratory, The August Krogh Institute, DK-2100 Copenhagen O, Denmark Department of Pathology, Rigshospitalet, DK-2100 Copenhagen O, Denmark Life Sciences Division, Berkeley National Laboratory, Berkeley, CA 94720, USA Author for correspondence (e-mail: o.w.petersen@mai.ku.dk) LBNL/DOE funding & contract number: DE-AC02-05CH11231read more
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The extracellular matrix at a glance
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Collective cell migration in morphogenesis, regeneration and cancer
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Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
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Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
Mina J. Bissell,William C. Hines +1 more
TL;DR: How normal tissue homeostasis and architecture inhibit progression of cancer and how changes in the microenvironment can shift the balance of these signals to the procancerous state are reviewed.
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Molecular characterization of the tumor microenvironment in breast cancer
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References
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Journal ArticleDOI
The extracellular matrix at a glance
TL;DR: The extracellular matrix is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue development.
Journal ArticleDOI
Collective cell migration in morphogenesis, regeneration and cancer
Peter Friedl,Darren Gilmour +1 more
TL;DR: Comparing different types of collective migration at the molecular and cellular level reveals a common mechanistic theme between developmental and cancer research.
Journal ArticleDOI
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
TL;DR: A collection of protocols to culture MCF-10A cells, to establish stable pools expressing a gene of interest via retroviral infection, as well as to grow and analyzeMCF- 10A cells in three-dimensional basement membrane culture are provided.
Journal ArticleDOI
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
Mina J. Bissell,William C. Hines +1 more
TL;DR: How normal tissue homeostasis and architecture inhibit progression of cancer and how changes in the microenvironment can shift the balance of these signals to the procancerous state are reviewed.
Journal ArticleDOI
Molecular characterization of the tumor microenvironment in breast cancer
Minna Allinen,Rameen Beroukhim,Li Cai,Cameron Brennan,Jaana Lahti-Domenici,Haiyan Huang,Haiyan Huang,Dale Porter,Min Hu,Lynda Chin,Andrea L. Richardson,Stuart J. Schnitt,William R. Sellers,William R. Sellers,Kornelia Polyak +14 more
TL;DR: Despite the dramatic gene expression changes in all cell types, genetic alterations were detected only in cancer epithelial cells and chemokines may play a role in breast tumorigenesis by acting as paracrine factors.