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Normal and tumor-derived myoepithelial cells differ in their ability to interact withluminal breast epithelial cells for polarity and basement membrane deposition

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TLDR
Gudjonsson et al. as discussed by the authors showed that normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition.
Abstract
Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition Thorarinn Gudjonsson 1 , Lone Ronnov-Jessen 2 , Rene Villadsen1, Fritz Rank 3 , Mina J. Bissell 4 and Ole William Petersen 1,* Structural Cell Biology Unit, Institute of Medical Anatomy, The Panum Institute, DK-2200 Copenhagen N, Denmark Zoophysiological Laboratory, The August Krogh Institute, DK-2100 Copenhagen O, Denmark Department of Pathology, Rigshospitalet, DK-2100 Copenhagen O, Denmark Life Sciences Division, Berkeley National Laboratory, Berkeley, CA 94720, USA Author for correspondence (e-mail: o.w.petersen@mai.ku.dk) LBNL/DOE funding & contract number: DE-AC02-05CH11231

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References
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Journal ArticleDOI

The extracellular matrix at a glance

TL;DR: The extracellular matrix is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue development.
Journal ArticleDOI

Collective cell migration in morphogenesis, regeneration and cancer

TL;DR: Comparing different types of collective migration at the molecular and cellular level reveals a common mechanistic theme between developmental and cancer research.
Journal ArticleDOI

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

TL;DR: A collection of protocols to culture MCF-10A cells, to establish stable pools expressing a gene of interest via retroviral infection, as well as to grow and analyzeMCF- 10A cells in three-dimensional basement membrane culture are provided.
Journal ArticleDOI

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

TL;DR: How normal tissue homeostasis and architecture inhibit progression of cancer and how changes in the microenvironment can shift the balance of these signals to the procancerous state are reviewed.
Journal ArticleDOI

Molecular characterization of the tumor microenvironment in breast cancer

TL;DR: Despite the dramatic gene expression changes in all cell types, genetic alterations were detected only in cancer epithelial cells and chemokines may play a role in breast tumorigenesis by acting as paracrine factors.