Normovolemic modified ultrafiltration is associated with better preserved platelet function and less postoperative blood loss in patients undergoing complex cardiac surgery: a randomized and controlled study.
Christian F Weber,Csilla Jámbor,Christian Strasser,Anton Moritz,Nestoras Papadopoulos,Kai Zacharowski,Dirk Meininger +6 more
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TLDR
N-MUF improved general platelet aggregation and reduced postoperative blood loss in a significant manner, however, performing N- MUF did not result in less postoperative transfusion requirements.About:
This article is published in The Journal of Thoracic and Cardiovascular Surgery.The article was published on 2011-05-01 and is currently open access. It has received 16 citations till now. The article focuses on the topics: Hemostasis.read more
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Use of modified ultrafiltration in adults undergoing coronary artery bypass grafting is associated with inflammatory modulation and less postoperative blood loss: a randomized and controlled study
Anali Galluce Torina,Lindemberg da Mota Silveira-Filho,Karlos Alexandre de Souza Vilarinho,Pirooz Eghtesady,Pedro Paulo Martins de Oliveira,Andrei C. Sposito,Orlando Petrucci +6 more
TL;DR: Use of MUF was associated with increased inflammatory response, reduced blood loss, and less blood transfusions in adults undergoing coronary artery bypass grafting.
Journal ArticleDOI
The effect of normovolemic modified ultrafiltration on inflammatory mediators, endotoxins, terminal complement complexes and clinical outcome in high-risk cardiac surgery patients
TL;DR: N-MUF leads to a significant reduction of lipopolysaccharide-binding protein and terminal complement complex and was associated with reduced blood loss and postoperative lactate concentrations shortly after surgery.
Journal ArticleDOI
Patient Blood Management in Cardiac Surgery
TL;DR: To optimize the risk-benefit ratio of allogeneic blood transfusion and to reduce associated costs, the implementation of PBM programs compromising a multidisciplinary and multifactorial approach including interventions before, during, and after surgery is suggested.
Journal ArticleDOI
Modified Ultrafiltration in Coronary Artery Bypass Grafting: A Randomized, Double-Blinded, Controlled Clinical Trial
Ali Sadeghpour Tabaei,Meysam Mortazian,Alireza Yaghoubi,Farhad Gorjipour,Shaghayegh Arasteh Manesh,Ziae Totonchi,Bahador Baharestani,Mohammad Javad Mehrabanian,Hamidreza Pazoki-Toroudi,Hossein Kaveh,Yaser Toloueitabar,Ameneh Ghanbari,Fazel Gorjipour +12 more
TL;DR: In this article, the authors investigated the effect of Modified Ultrafiltration (MUF) and its effects on inflammatory cytokine response, hemodilution and rotational thromboelastometry outcomes in adults' CABG operation.
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Platelet Function in Stored Heparinised Autologous Blood Is Not Superior to in Patient Platelet Function during Routine Cardiopulmonary Bypass
TL;DR: Ex vivo preservation of autologous blood in unfractionated heparin does not seem to be profitable to preserve platelet function.
References
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The electronic aggregometer: a novel device for assessing platelet behavior in blood.
TL;DR: The new technique is very suitable for investigating platelet pharmacology, since the inhibitors of aggregation, such as indomethacin and prostacyclin, can be conveniently quantitated in blood by using this technique.
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Reexploration for bleeding is a risk factor for adverse outcomes after cardiac operations.
TL;DR: Reexploration for bleeding was identified as a strong independent risk factor for operative mortality and application of recently developed modalities designed to facilitate perioperative correction of coagulopathy could improve outcomes after cardiac operations.
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Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass
Jane C. K. Fitch,Scott A. Rollins,Louis A. Matis,Bernadette Alford,Sary F. Aranki,Charles D. Collard,Michael L. Dewar,John A. Elefteriades,Roberta Hines,Gary S. Kopf,Philip Kraker,Lan Li,Ruth O'Hara,Christine S. Rinder,Henry M. Rinder,Richard K. Shaw,Brian G. Smith,Gregory L. Stahl,Stanton K. Shernan +18 more
TL;DR: C5 inhibition significantly attenuates postoperative myocardial injury, cognitive deficits, and blood loss and suggests that C5 inhibition may represent a novel therapeutic strategy for preventing complement-mediated inflammation and tissue injury.
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The inflammatory response to cardiopulmonary bypass: part 1--mechanisms of pathogenesis.
Oliver Warren,Andrew Smith,Christos Alexiou,Paula Rogers,Noorulhuda Jawad,Charles Vincent,Ara Darzi,Thanos Athanasiou +7 more
TL;DR: What was once a perilous, experimental procedure has been transformed into a relatively standard medical act, performed on more than half a million patients worldwide per year, because of a number of major factors.
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High-volume, zero-balanced hemofiltration to reduce delayed inflammatory response to cardiopulmonary bypass in children.
Didier Journois,Dominique Israel-Biet,Philippe Pouard,Benedicte Rolland,William Silvester,Pascal Vouhé,D. Safran +6 more
TL;DR: It is suggested that hemofiltration exerts some beneficial clinical effects that are not due to water removal and the role of the early removal of factors triggering the inflammatory response, rather than a direct removal of cytokines, deserves further investigation.