Journal ArticleDOI
Novel web-based tools combining chemistry informatics, biology and social networks for drug discovery.
TLDR
This work argues that a community-based platform that combines traditional drug discovery informatics with Web2.0 features in secure groups is believed to be the key to facilitating richer, instantaneous collaborations involving sensitive drug discovery data and intellectual property.About:
This article is published in Drug Discovery Today.The article was published on 2009-03-01. It has received 133 citations till now. The article focuses on the topics: Informatics.read more
Citations
More filters
Journal ArticleDOI
In silico repositioning of approved drugs for rare and neglected diseases
TL;DR: It is suggested here that with current in silico technologies and databases of the structures and biological activities of chemical compounds (drugs) and related data, as well as close integration with in vitro screening data, improved opportunities for drug repurposing will emerge for neglected or rare/orphan diseases.
Journal ArticleDOI
Materials Data Science: Current Status and Future Outlook
Surya R. Kalidindi,Marc De Graef +1 more
TL;DR: The concept of process-structure-property (PSP) linkages is introduced and illustrated how the determination of PSPs is one of the main objectives of materials data science.
Journal ArticleDOI
In silico drug repositioning: what we need to know.
Zhichao Liu,Hong Fang,Kelly Reagan,Xiaowei Xu,Xiaowei Xu,Donna L. Mendrick,William Slikker,Weida Tong +7 more
TL;DR: The proposed steps are aimed at providing a repurposing pipeline, with particular focus on the proposed Drugs of New Indications (DNI) database, which can be used alongside currently available resources to improve in silico drug repositioning.
Journal ArticleDOI
Data-driven medicinal chemistry in the era of big data
TL;DR: Data-driven medicinal chemistry approaches have the potential to improve decision making in drug discovery projects, providing that all researchers embrace the role of 'data scientist' and uncover the meaningful relationships and patterns in available data.
Journal ArticleDOI
Recent advancements in the development of anti-tuberculosis drugs.
TL;DR: An overview of tuberculosis is provided highlighting the recent advances and tools that are employed in the field of anti-tuberculosis drug discovery, i.e. anti-Tuberculosis agents that are currently in the pipeline and clinical trials.
References
More filters
Journal ArticleDOI
Network biology: understanding the cell's functional organization
TL;DR: This work states that rapid advances in network biology indicate that cellular networks are governed by universal laws and offer a new conceptual framework that could potentially revolutionize the view of biology and disease pathologies in the twenty-first century.
Journal ArticleDOI
The Impact of Research Collaboration on Scientific Productivity
Sooho Lee,Barry Bozeman +1 more
TL;DR: Based on the curricula vitae and survey responses of 443 academic scientists affiliated with university research centers in the USA, the authors examined the longstanding assumption that research collaborati cation is collaborative.
Journal ArticleDOI
The KEGG databases at GenomeNet
TL;DR: The Kyoto Encyclopedia of Genes and Genomes (KEGG) is the primary database resource of the Japanese GenomeNet service for understanding higher order functional meanings and utilities of the cell or the organism from its genome information.
Journal ArticleDOI
Team assembly mechanisms determine collaboration network structure and team performance.
Roger Guimerà,Brian Uzzi,Brian Uzzi,Jarrett Spiro,Jarrett Spiro,Luís A. Nunes Amaral,Luís A. Nunes Amaral +6 more
TL;DR: A model for the self-assembly of creative teams that has its basis in three parameters: team size, the fraction of newcomers in new productions, and the tendency of incumbents to repeat previous collaborations is proposed.
Journal ArticleDOI
New uses for old drugs
TL;DR: It takes too long and costs too much to bring new drugs to market, so let's beef up efforts to screen existing drugs for new uses, argue Curtis R. Chong and David J. Sullivan Jr.