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Open AccessJournal ArticleDOI

Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: In vitro effect and stability to gastrointestinal enzymes

Tânia G. Tavares, +6 more
- 01 May 2011 - 
- Vol. 32, Iss: 5, pp 1013-1019
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TLDR
Whey protein concentrate was subjected to enzymatic hydrolysis by proteases from the flowers of Cynara cardunculus, and the resulting angiotensin-converting enzyme (ACE)-inhibitory effect was monitored, finding three novel, highly potent peptides that remained stable in the presence of gastrointestinal enzymes.
About: 
This article is published in Peptides.The article was published on 2011-05-01 and is currently open access. It has received 133 citations till now. The article focuses on the topics: Whey protein & Hydrolysate.

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Journal ArticleDOI

Whey as a source of peptides with remarkable biological activities

Adriano Brandelli, +2 more
- 01 Jul 2015 - 
TL;DR: In this article, the main biological activities of peptides derived from whey proteins are discussed, including immunomodulatory, anticancer, opioid and hypocholesterolemic activities.
Book ChapterDOI

Milk Protein Hydrolysates and Bioactive Peptides

Alice B. Nongonierma, +2 more
TL;DR: Detailed knowledge of the peptide sequences responsible for the bioactive properties, together with a better understanding of the bioavailability and stability of these peptides in vivo may help to enhance the development of milk protein hydrolysates with health promoting capabilities in humans.
Journal ArticleDOI

Whey protein hydrolysates as a source of bioactive peptides for functional foods – Biotechnological facilitation of industrial scale-up

Anja Dullius, +2 more
- 01 Mar 2018 - 
TL;DR: The requirements of industrial processes regarding peptide release and stability, depending on several process parameters, are summarized, and some enrichment techniques for whey-derived peptides that are potentially applicable to industry are considered.
Journal ArticleDOI

Possible role of milk‐derived bioactive peptides in the treatment and prevention of metabolic syndrome

Ignacio Ricci-Cabello, +2 more
- 01 Apr 2012 - 
TL;DR: This review summarizes the current knowledge on bioactive peptides derived from milk proteins and examines the potential value of these peptides in the treatment and prevention of metabolic syndrome and its complications.
Journal ArticleDOI

Peptidomics for discovery, bioavailability and monitoring of dairy bioactive peptides

Laura Sánchez-Rivera, +4 more
- 01 Sep 2014 - 
TL;DR: The objective of this review is to highlight the increasing role of peptidomics as indispensable tool in the fields of discovery, bioavailability and monitoring of dairy bioactive peptides.
References
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Journal ArticleDOI

Proposal for a common nomenclature for sequence ions in mass spectra of peptides.

Roepstorff P, +1 more
Journal ArticleDOI

Bioactive peptides: Production and functionality

Hannu J. T. Korhonen, +1 more
- 01 Sep 2006 - 
TL;DR: A variety of naturally formed bioactive peptides have been found in fermented dairy products, such as yoghurt, sour milk and cheese as mentioned in this paper, but the health benefits attributed to peptides in these traditional products have, so far, not been established, however.
Journal ArticleDOI

Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence.

H S Cheung, +4 more
- 25 Jan 1980 - 
TL;DR: Results suggest that selective binding of the COOH-terminal dipeptide residue is an impor tan t dete rminant of both the substrate specificity of angiotensin-converting enzyme and the degree of rate stimulation by chloride ion, and that the nature of this selective binding can be further clarified by studying competitive inhibition of dpeptides of vary ing structure.
Journal ArticleDOI

Bioactive Milk Peptides: A Prospectus

Debra A. Clare, +1 more
- 01 Jun 2000 - 
TL;DR: This work reviews the scientific literature and attempts to stimulate consideration of the continued use of bioactive peptides and their expanded development as a commercial product.
Journal ArticleDOI

Milk-derived bioactive peptides: From science to applications

Hannu J. T. Korhonen
- 01 Apr 2009 - 
TL;DR: A great variety of naturally formed bioactive peptides have been found in fermented dairy products, such as yoghurt, sour milk and cheese as mentioned in this paper, and industrial-scale technologies suitable for the industrial production of bioactive milk peptide have been developed.
Related Papers (5)

Preparation of antioxidant enzymatic hydrolysates from alpha-lactalbumin and beta-lactoglobulin. Identification of active peptides by HPLC-MS/MS.

Blanca Hernández-Ledesma, +3 more
- 14 Jan 2005 - 

Bioactive peptides derived from bovine whey proteins: opioid and ace-inhibitory peptides.

Anne Pihlanto-Leppälä
- 10 Sep 2000 - 

Hypotensive Peptides from Milk Proteins

Richard J. FitzGerald, +2 more
- 01 Apr 2004 - 

Antioxidative peptides from food proteins: a review

Bahareh Sarmadi, +1 more
- 01 Oct 2010 - 

Bioactive peptides: Production and functionality

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- 01 Sep 2006 - 
Frequently Asked Questions (1)
Q1. What are the contributions mentioned in the paper "Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: in vitro effect and stability to gastrointestinal enzymes" ?

In this paper, a wheat protein concentrate ( WPC ) was subjected to enzymatic hydrolysis by proteases from the flowers of Cynara cardunculus, and the resulting angiotensin-converting enzyme ( ACE ) -inhibitory effect was monitored.