Journal ArticleDOI
On the mammalian acetone metabolism: from chemistry to clinical implications.
TLDR
A trial is made to ascertain a comprehensive overview of acetone research extending discussion from chemistry to clinical implications and the possible future directions of research upon acetone are depicted by emphasizing the need for the clear-cut identification of mammalian acetoacetate decarboxylase, and the investigation of race differences and genetic background of acet one metabolism.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2003-05-02. It has received 217 citations till now. The article focuses on the topics: Acetoacetate decarboxylase & Isopropyl alcohol.read more
Citations
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Journal ArticleDOI
Determination of acetone in human breath by gas chromatography-mass spectrometry and solid-phase microextraction with on-fiber derivatization.
TL;DR: The results show that GC-MS and SPME with on-fiber derivatization is a simple, rapid and sensitive and solvent-free method for determination of low concentration acetone in breath and analysis of breath acetone can be used as supplementary tool for diagnosis of diabetes.
Journal ArticleDOI
A longitudinal study of ammonia, acetone and propanol in the exhaled breath of 30 subjects using selected ion flow tube mass spectrometry, SIFT-MS.
TL;DR: The findings indicate the potential value of SIFT-MS as a non-invasive breath analysis technique for investigating volatile compounds in human health and in the diseased state.
Book ChapterDOI
Chaperone-mediated autophagy in aging and disease.
TL;DR: Current findings on the molecular mechanisms for CMA are covered and the possible pathophysiological relevance of this selective lysosomal degradation is covered.
Journal ArticleDOI
Isoprene and acetone concentration profiles during exercise on an ergometer
Julian King,Alexander Kupferthaler,Alexander Kupferthaler,Karl Unterkofler,Karl Unterkofler,Helin Koc,Helin Koc,Helin Koc,Susanne Teschl,Gerald Teschl,Wolfram Miekisch,Wolfram Miekisch,Jochen K. Schubert,Jochen K. Schubert,Hartmann Hinterhuber,Hartmann Hinterhuber,Anton Amann,Anton Amann +17 more
TL;DR: Data appear to favor the hypothesis that short-term effects visible in breath isoprene levels are mainly caused by changes in pulmonary gas exchange patterns rather than fluctuations in endogenous synthesis, and hold great potential in capturing continuous dynamics of non-polar, low-soluble VOCs over a wide measurement range.
Journal ArticleDOI
Breath analysis in disease diagnosis: methodological considerations and applications.
Célia Lourenço,Claire Turner +1 more
TL;DR: This review describes recent scientific developments in basic research and clinical applications, namely issues concerning sampling and biochemistry, highlighting the diagnostic potential of breath analysis for disease diagnosis.
References
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Book
The Merck index
TL;DR: This CD-ROM provides the tools to draw structures and then search for them, and presents over 10,000 monographs which detail chemicals, drugs and biologicals, and describe a single substance or small group of related compounds.
Journal ArticleDOI
Physiological roles of ketone bodies as substrates and signals in mammalian tissues.
A M Robinson,D H Williamson +1 more
Journal ArticleDOI
Methylglyoxal in living organisms: chemistry, biochemistry, toxicology and biological implications.
TL;DR: A comprehensive overview of methylglyoxal research, extending discussion from chemistry to biological implications by reviewing some important characteristics of methyl glyoxal metabolism and toxicity in a wide variety of species, and emphasizing the action of methyl-oxoaldehyde production in the environment as a potential risk factor and to the possible role of this a-dicarbonyl in diseases as discussed by the authors.
Journal ArticleDOI
Range-Finding Toxicity Data: List VII
TL;DR: In this article, acute toxicity and irritation data on about 200 compounds are presented, accumulated in a continuing program for screening potential commercial products, and the authors present a detailed discussion of the results.