On the Specificity of the Oxygenation of Unsaturated Fatty Acids Catalyzed by Soybean Lipoxidase
Mats Hamberg,Bengt Samuelsson +1 more
TLDR
The conversion of [13l-3H, 3-14C]8,11,14-eicosatrienoic acid is accompanied by an isotope effect, suggesting that the hydrogen removal occurs as the initial step of the reaction, and only the hydrogen of the l configuration is removed by the enzyme during the conversion.About:
This article is published in Journal of Biological Chemistry.The article was published on 1967-11-25 and is currently open access. It has received 633 citations till now. The article focuses on the topics: Fatty acid & Substrate (chemistry).read more
Citations
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The lipoxygenase pathway.
Ivo Feussner,Claus Wasternack +1 more
TL;DR: Activation of this pathway as an initial step in the interaction of plants with pathogens, insects, or abiotic stress and at distinct stages of development are reviewed.
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Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells: AUTACOIDS IN ANTI-INFLAMMATION *
TL;DR: It is indicated that DHA is the precursor to potent protective mediators generated via enzymatic oxygenations to novel docosatrienes and 17Sseries resolvins that each regulate events of interest in inflammation and resolution.
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Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides
TL;DR: It is concluded that a balance between formation by arterial walls of PGX which prevents platelet aggregation and release by blood platelets of prostaglandin endoperoxides which induce aggregation is of the utmost importance for the control of thrombus formation in vessels.
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Leukotriene C: a slow-reacting substance from murine mastocytoma cells.
TL;DR: In this paper, the slow-reacting substance (SRS) that caused guinea pig ileum to contract was identified as a cysteine-containing derivative of 5-hydroxy-7,9,11,14-icosatetraenoic acid.
Journal ArticleDOI
Prostaglandins, aspirin-like drugs and analgesia.
TL;DR: Compared the pain producing activity of fatty acid hydroperoxides with that of high concentrations of acetylcholine, bradykinin, histamine and PGE1 on intradermal injection in man, the intensity of the pain induced was greater than that induced by the other agonists but for all except P GE1 the pain was transitory.
References
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Approaches to the Total Synthesis of Adrenal Steroids.1 V. 4b-Methyl-7- ethylenedioxy-1,2,3,4,4aα,4b,5,6,7,8,10,10a β-dodecahydrophenanthrene-4 β-ol-1-one and Related Tricyclic Derivatives
Journal ArticleDOI
On the Mechanism of the Biosynthesis of Prostaglandins E1 and F1α
Mats Hamberg,Bengt Samuelsson +1 more
TL;DR: It is suggested that 11-peroxy-8,12,14-eicosatrienoic acid is the first intermediate in the conversion, which is eventually transformed into PGE1 or PGF1α by independent reactions.
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Use of a Mass Spectrometer as a Detector and Analyzer for Effluent Emerging from High Temperature Gas Liquid Chromatography Columns.
Journal ArticleDOI
Oxygenation of Unsaturated Fatty Acids by the Vesicular Gland of Sheep
Mats Hamberg,Bengt Samuelsson +1 more
TL;DR: These experiments showed that C-9, C-10, and C-11 are eliminated from the precursor and that the stereochemistry of the removal of hydrogen from C-13 is identical with that occurring during the biosynthesis of PGE1.
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On the transformation and enterohepatic circulation of cholic acid in the rat: bile acids and steroids 68.
Arne Norman,J. Sjövall +1 more
TL;DR: The aim of the present investigation was to find out where these transformations take place, and to ascertain the nature of the products formed and whether these products are reabsorbed so as to take part in the enterohepatic circulation.
Related Papers (5)
Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets
Mats Hamberg,Bengt Samuelsson +1 more