Journal ArticleDOI
On the synthesis of 3(5)-carbomethoxy-4-hetarylpyrazoles
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TLDR
In this paper, an explanation for the different reactivity of dipolarophiles with diazomethane is given, based on FMO theory and an explanation of the different reactionivity of the dipolarophile with methyl Z-2-benzamido-3-hetylpropenoates is given.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 1988-05-01. It has received 17 citations till now. The article focuses on the topics: 1,3-Dipolar cycloaddition & Reactivity (chemistry).read more
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Patent
Substituted pyrazoles as p38 kinase inhibitors
Anantanarayan Ashok,John E. St. Louis Baldus,Michael Clare,Paul W. Collins,Joyce Z. Crich,Rajesh Ballwin Devraj,Daniel L. Flynn,Lifeng Geng,Matthew J. Graneto,Cathleen E. Hanau,Gunnar J. Hanson,Susan J. Hartmann,Michael St. Charles Hepperle,He Huang,Kevin D. Jerome,Ish K. Khanna,Francis J. Koszyk,Shuyuan Liao,Suzanne Metz,Win Naing,Richard A. Partis,Thao D. Perry,Shashidhar N. Rao,Shaun R. Selness,Michael S. Chesterfield South,Stealey Michael A,John J. Talley,Vazquez Michael L,John K. Walker,Richard M. Weier,Xiangdong Gurnee Xu,Syaulan Chesterfield Yang,Yi Glenview Yu +32 more
TL;DR: A class of pyrazole derivatives described for use in treating p38 kinase mediated disorders are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
Patent
Pyrazole derivatives as p38 kinase inhibitors
Gunnar J. Hanson,Shuyuan Liao +1 more
TL;DR: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders in this paper, where compounds of particular interest are defined by Formula (I) wherein Q, R1, R2, R3 and R4 are as described in the specification.
Journal ArticleDOI
Synthesis and antimicrobial activity of some new 4-hetarylpyrazole and furo[2,3-c]pyrazole derivatives.
TL;DR: Two compounds prepared via the reaction of 2-chloro-1-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-yl)ethanone and furo[2,3-c]pyrazoles were found to exhibit the most potent in vitro antifungal activity with MICs.
Journal ArticleDOI
Reaction of substituted furan-2-carboxaldehydes and furo[b]pyrrole type aldehydes with hippuric acid.
TL;DR: 2D NMR spectroscopic measurements confirmed that the configuration at the carbon-carbon double bond corresponds to the pure E isomers of the products, and showed that microwave irradiation shortens the reaction times while affording comparable yields.
Journal ArticleDOI
Cycloaddition dipolaire 1,3 des 4-arylidene oxazol-5- ones avec la diphenylnitrilimine
N Baba,M Soufiaoui +1 more
TL;DR: The 1,3 dipolar cycloaddition of 4-arylidene oxazol-5-ones with diphenylnitrilimine is regiospecific and gives one adduct as discussed by the authors.
References
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Journal ArticleDOI
Diels‐Alder reactions II: The Reaction Mechanism
TL;DR: The possible mechanisms of the preparatively so productive Diels-Alder reactions are discussed critically on the basis of experimental data as discussed by the authors, although most of the facts can be explained readily by a synchronous mechanism, a number of problems remains.
Journal ArticleDOI
Ground states of molecules. 53.MNDO calculations for molecules containing chlorine
Michael J. S. Dewar,Henry Rzepa +1 more
TL;DR: In this article, MNDO calculations of formation, dipole moments, ionization potentials, and structures are reported for a wide range of compounds containing chlorine in its characteristic valence state (ClI) and one or more of the elements H, B, Be, C, N, O, and F.
Journal ArticleDOI
Conformational flexibility of the dehydroalanine derivatives: molecular and electronic structure of (Z)-N-acetyldehydrophenylalanine
TL;DR: In this article, the molecular structure of (Z)-N-acetyldehydrophenylalanine (1-phenyl-2,acetylaminoprop-2-enoic acid) has been determined from three-dimensional X-ray data.
Journal ArticleDOI
Effect of electronic state of carbon atoms on their reactions with cyclopentadiene in inert gas moderated systems
Timothy L. Rose,Colin MacKay +1 more
Journal ArticleDOI
New Efficient Synthesis of 3(5)-Carbomethoxy-4-Aryl Pyrazoles from 3-Aryl-2,3-Dehydroamino Acid Derivatives
TL;DR: In this article, 3(5)-Carbomethoxy-4-arylpyrazoles can be easily obtained by aromatization with boron trifluoride etherate of 4-aryl-3-acetamido(or benzamido)-3-carbo-methoxy-Δ-pyrazolines synthesized by 1,3-dipolar cyclo addition of diazomethane with 3-aryl 2,3dehydroamino acid derivatives.