Journal ArticleDOI
Ontogenic profile of some antioxidants and lipid peroxidation in human placental and fetal tissues
Suparna Qanungo,Manju Mukherjea +1 more
TLDR
Results indicate that there is gradual suppression of lipoperoxide formation with the progress of gestation to protect the fetus against oxygen toxicity.Abstract:
Reactive oxygen species (ROS) pose a serious threat to maternal and fetal health during pregnancy. However, there is little information on the oxidative damage caused by ROS and its protection during prenatal life. The present study highlights the status of various antioxidants in human placental and fetal tissues at different phases of gestation. The activity profile of scavenging enzymes, superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase as well as the concentrations of non-enzymatic antioxidants, ascorbic acid, α-tocopherol, bilirubin and glutathione have been determined in human placental whole homogenate, placental brush border membrane and fetal liver over gestational periods ranging from 6 weeks of pregnancy till birth. The ontogenic profile of lipid peroxidation, a marker of oxidative damage has also been investigated in the feto-placental system. Catalase, superoxide dismutase and glutathione reductase activities increased significantly, but glutathione peroxidase activity remained almost the same throughout development. Except α- tocopherol and bilirubin, the concentrations of other non-enzymic scavengers followed a significant increasing trend with advancement of pregnancy. Results indicate that there is gradual suppression of lipoperoxide formation with the progress of gestation to protect the fetus against oxygen toxicity.read more
Citations
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Journal ArticleDOI
The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes
TL;DR: The role of ROS in female reproductive processes and the state of knowledge on the association between ROS, oxidative stress, antioxidants and pregnancy outcomes in different mammalian species are summarized.
Journal ArticleDOI
Iron and Oxidative Stress in Pregnancy
TL;DR: Estimates of gestational iron requirements and of the proportion of iron absorbed from different iron supplemental doses suggest that with present supplementation schemes the intestinal mucosal cells are constantly exposed to unabsorbed iron excess and oxidative stress.
Journal ArticleDOI
Maturation of the antioxidant system and the effects on preterm birth.
TL;DR: Improved understanding of the role of antioxidant systems during fetal and neonatal development is necessary for the development of rational treatments aimed at improving pregnancy outcomes and reducing the burden of oxidative stress to premature newborns.
Journal ArticleDOI
The Human First Trimester Gestational Sac Limits Rather than Facilitates Oxygen Transfer to the Foetus—A Review
TL;DR: In this article, it was shown that the structure of the human first trimester gestational sac limits foetal exposure to oxygen to what is strictly necessary for its development, which is in agreement with the concept that the placenta and foetus develop in a physiologically low O2 environment.
The human first trimester gestational sac limits rather than facilitates oxygen transfer to the fetus: a review
TL;DR: Comparison of morphological features with physiological findings reveals that the architecture of the human first trimester gestational sac is designed to limit foetal exposure to oxygen to that which is strictly necessary for its development, and that during early pregnancy alternative nutritional pathways are in use.
References
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Book ChapterDOI
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