Journal ArticleDOI
Ontogeny of cellular immunity in the human fetus: development of responses to phytohemagglutinin and to allogeneic cells.
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All lymphoid cells studied showed stimulatory ability in the mixed lymphocyte reaction, however, spleen, blood, and marrow cells produced higher stimulation of allogeneic cells than did thymic or hepatic cells.About:
This article is published in Cellular Immunology.The article was published on 1974-03-30. It has received 97 citations till now. The article focuses on the topics: Allogeneic Lymphocyte & Bone marrow.read more
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Journal ArticleDOI
The development of the immune system during pregnancy and early life.
Patrick G. Holt,C. A. Jones +1 more
TL;DR: This review contrasts the published data obtained from studies on fetal and newborn peripheral blood mononuclear cells with the more limited information available on samples from infants and young children.
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Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure
TL;DR: The available animal data suggest the potential for altered postnatal immune function in humans exposed to immunotoxicants (e.g., environmental chemicals and therapeutic agents) during fetal and/or early postnatal life.
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Species comparison of anatomical and functional immune system development
TL;DR: The anatomical and functional development of the immune system in several species important to either preclinical studies for drug development or safety assessments for chemicals, with what is known in humans are compared.
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Ontogeny of mouse lymphocyte function. II. Development of the ability to produce antibody is modulated by T lymphocytes.
Donald E. Mosier,B M Johnson +1 more
TL;DR: Small numbers of neonatal spleen T cells or thymocytes significantly decreased the in vitro antibody response of adult spleen cells, indicating suppression activity attributable to T cells seems to play a dominant role in determining the ability of the neonatal animal to react positively or negatively to antigenic stimulation.
Journal ArticleDOI
Human breast milk: current concepts of immunology and infectious diseases.
TL;DR: A review of the immunologic activities and protective benefits of human breast milk against infection, and important concepts bout the developing immunity of infants, bioactive actors and antiinflammatory properties of breast milk, testinal microflora in infants, probiotics and prebiotcs, and the dynamic interactive effects of breast Milk n the developing infant are presented.
References
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Journal ArticleDOI
Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.
TL;DR: It is indirectly shown that all or at least a major population of human thymus-derived lymphocytes under certain conditions will form nonimmune rosettes with sheep red blood cells (SRBC), and it is suggested that these ro settes are formed by a rapidly released or metabolized receptor substance on the living cell surface which behaves as a trypsin-sensitive structure produced by the cells themselves.
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The Human Rosette-Forming Cell as a Marker of a Population of Thymus-Derived Cells
TL;DR: The results suggest that mu-chain determinants are present on human fetal thymocytes and blood RFC and lead to the hypothesis that human blood RFC may be chiefly thymic derived.
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Combined Studies of Complement Receptor and Surface Immunoglobulin-Bearing Cells and Sheep Erythrocyte Rosette-Forming Cells in Normal and Leukemic Human Lymphocytes
TL;DR: The finding of lymphocytes with only one of the two B cell markers suggests that these markers are not uniformly present on all B cells and that depending on the source, one or the other may be deficient.
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Histocompatibility matching. VI. Miniaturization of the mixed leukocyte culture test: a preliminary report.
TL;DR: A miniaturized method for the mixed leukocyte culture (MLC) test is described which results in substantial savings in cells, medium, and time.
Journal ArticleDOI
Thymus cell migration
TL;DR: In the newborn, the kinetic pattern is similar to that of adults, with the single distinction that large cells also migrate, accelerating the tempo of migration in these hosts, and the long-term fate and function of thymus cell migrants has not yet been determined.
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