Showing papers in "Cellular Immunology in 1974"

TL;DR: DNA labeling by 3 H-thymidine in vitro and antiglobulin- 131 I binding in vitro were used to determine the development and turnover of immunoglobulin -bearing lymphocytes in mouse bone marrow to demonstrate a continuous, rapid renewal of immunosorbent small lymphocyte in adult mouseBone marrow.

TL;DR: The results suggest largely independent pathways are involved in the development of the two antigenically defined subpopulations of mouse thymus, but do not support a direct transfer of “immature” high θ, TL positive small thymocytes in mature, active, lowθ,TL negative cells.

TL;DR: Those nude mice which had been injected with thymus cells made a much better secondary response, both for 19S and for 7S antibody, and had active germinal centers in their lymph nodes as early as 3 wk afterThymus cell injection.

TL;DR: The results demonstrate that many of the small lymphocytes in mouse bone marrow have readily detectable surface immunoglobulin molecules which vary considerably in density from cell to cell, while others neither have detectable surface immunity, nor are they θ -bearing, thymus-dependent or recirculating cells.

TL;DR: Using 51Cr-labelled P-815 mastocytoma cells as target cells and CS7BL/6 spleen cells sensitized against DBA/2 antigens as effector cells, it is shown that the variation in the observed specific 51Cr release over a broad range of experimental conditions can be explained on the basis of a simple physical model of the interaction process.

TL;DR: Small inert particles taken up and deposited throughout the medullary portion of bursal follicles are indicative of an antigen-driven development of the bursesal system protected by local bactericidal mechanisms.

TL;DR: The existence of immunoglobulin-binding factors at the surface of some T cells and in supernatants from T cells should be taken into consideration for the interpretation of results of experiments investigating immunoglOBulin production by T cells.

TL;DR: Thymus lymphocyte activating factor was obtained in supernatants from cultures of human leukocytes or mouse peritoneal cells and exhibited the following properties: A. Lymphocytes activating factor is stable at temperatures up to 37 °C, but is partially destroyed by heating at 60 or 80 °C.

TL;DR: It is indicated that most patients with cryptococcosis have a degree of deficiency in cell-mediated response to fungal antigens even when a specific underlying disease process cannot be identified.

TL;DR: T cells or T cell products are ineffective in inducing or accelerating B cell interferon or proliferative response at 3 days, and the use of 3-day T cell Interferon production as a new technique for the assessment of T cell effector function and competence is suggested.

TL;DR: The hypothesis suggests teleological reasons for the existence of the different types of immunity and suggests ways of controlling the type of response an antigen induces, including cell-mediated or humoral immunity.

TL;DR: Antigen-mediated macrophage adherence inhibition (MAI) was studied in inbred rats immunized with various transplantation, tumour-specific and protein antigens and seems to be due to the direct interaction of the respective antigen with a corresponding PC receptor.

TL;DR: All lymphoid cells studied showed stimulatory ability in the mixed lymphocyte reaction, however, spleen, blood, and marrow cells produced higher stimulation of allogeneic cells than did thymic or hepatic cells.

TL;DR: The two functions of the macrophage in MLC, its auxiliary helper role, and the elicitation of the reaction, may be dependent on one and the same mechanism.

TL;DR: Mice pretreated with iv Corynebacterium parvum showed markedly reduced DTH reactivity to subsequently injected SRBC without concomitantly increased antibody levels, and lymph nodes, even when directly stimulated by local injection of C.Parvum, were unable to substitute for the spleen in DTH depression.

TL;DR: Results indicate a function for serum transferrin in zinc metabolism, and a role for the zinc transferrin complex in lymphocyte metabolism, as judged by the uptake of tritiated thymidine.

TL;DR: The total number of B and T lymphocytes was significantly reduced when compared to normals, and the population of thymus-derived cells seems to be the one predominately affected.

TL;DR: A drop in per cent of RFC is coincident with a drop of thymic function; it should be taken in account whenever RFC are studied as a clinical test.

TL;DR: Peritoneal exudate cells obtained from rabbits injected intraperitoneally with mineral oil were separated into several subpopulations by equilibrium density centrifugation on continuous or discontinuous bovine serum albumin gradients, achieving highly reproducible separation of the cells into 5 subpopulation.

TL;DR: It is demonstrated that lymphocytes undergoing blastic transformation have increased HMPS activity which follows a predictable temporal pattern as does glucose consumption.

TL;DR: The designation as B lymphocytes for human lymphocytes with a large quantity of membrane-bound immunoglobulin seems justified, similar to those of bone marrow-derived and thymus-derived lymphocytes in mice.

TL;DR: This model of embryonic immunodeficiency will provide a possibility for a match according to the maturity of transplanted cells and of the microenvironment they require for further development in reconstitution studies.

TL;DR: A marked depression of phytohemagglutinin reactivity was observed in spleen cell cultures of mice bearing primary Moloney sarcoma virus (MSV)-induced tumors and may indicate that within MSV 14 spleens, T lymphocytes reactive to PHA and Con A are diluted out by a majority of unreactive cells.

TL;DR: LMF produced in response to stimulation with a specific antigen is able to cooperate with more than one antigen in recruiting cells into division and is a nondialyzable protein different from other lymphokines as judged by the kinetics of its release.

TL;DR: The relationship between the epitope density of hapten-protein conjugates, and their immunogenicity in mice has been investigated, and antibody production to both DNP 5 BSA and DNP 50 BSA is highly thymus dependent.

TL;DR: Serum from mice after tumor removal lacked the ability to block the leucocyte adherence inhibition reaction, but specifically reversed the effect of blocking serum (unblocking), so three important phenomena of tumor immunity are now detectable by a brief, simple procedure.

TL;DR: Significantly less listericidal factor was released by monolayers of peritoneal cells from BCG-immune guinea pigs following incubation with PPD in cell culture, and supernatants from cultures of guinea pig fibroblasts or ascites-form hepatoma were not listersicidal.

TL;DR: Protected guinea pigs had intact cell-mediated immunity to BPM, as measured by inhibition of macrophage migration in vitro, and the mechanism of protection may involve the production, following injection of BPM in IFA, of a class of suppressor thymic lymphocytes capable of overriding otherwise encephalitogenic thymi lymphocytes.