Optic nerve head blood flow using a laser Doppler velocimeter and haemorheology in primary open angle glaucoma and normal pressure glaucoma.
TLDR
The results in POAG patients and NPG patients showed that their optic nerve blood flow velocity was reduced and that the aggregability of the RBCs was increased, which supports the hypothesis of a vasogenic mechanism that could impair the optic nerve in glaucoma patients.Abstract:
Optic disc blood flow velocity was measured in healthy patients, those with primary open angle glaucoma (POAG), and patients with normal pressure glaucoma (NPG). The velocity of the red blood cells (RBCs) in the capillaries of the optic nerve head (ONH) has been measured with a laser Doppler velocimeter (LDV), and blood viscosity has been evaluated notably by determining the aggregability of the RBCs with an erythroaggregameter. Our results in POAG patients and NPG patients showed that their optic nerve blood flow velocity was reduced and that the aggregability of the RBCs was increased. The hyperaggregability of the erythrocytes is responsible for the increase of the local viscosity in the papillary capillary network. These haemodynamic modifications observed in patients with glaucoma support the hypothesis of a vasogenic mechanism that could impair the optic nerve in glaucoma patients.read more
Citations
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Journal ArticleDOI
The impact of ocular blood flow in glaucoma.
Josef Flammer,Selim Orgül,Vital Paulino Costa,Nicola Orzalesi,Günter K. Krieglstein,Luis Metzner Serra,Jean-Paul Renard,Einar Stefánsson +7 more
TL;DR: The potential role of OBf in glaucoma is discussed and how a disturbance of OBF could increase the optic nerve's sensitivity to IOP is discussed.
Journal ArticleDOI
Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma
Yali Jia,Eric Wei,Xiaogang Wang,Xinbo Zhang,John C. Morrison,Mansi Parikh,Lori H. Lombardi,Devin M. Gattey,Rebecca L. Armour,Beth Edmunds,Martin F. Kraus,Martin F. Kraus,James G. Fujimoto,David Huang +13 more
TL;DR: Optical coherence tomography angiography, generated by the new SSADA, repeatably measures optic disc perfusion and may be useful in the evaluation of glaucoma and glAUcoma progression.
Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma
Yali Jia,Eric Wei,Xiaogang Wang,Xinbo Zhang,John C. Morrison,Mansi Parikh,Lori H. Lombardi,Devin M. Gattey,Rebecca L. Armour,Beth Edmunds,Martin F. Kraus,Martin F. Kraus,James G. Fujimoto,David Huang +13 more
TL;DR: In this paper, the authors compared optic disc perfusion between normal subjects and subjects with glaucoma using optical coherence tomography (OCT) angiography and to detect optic disc percutaneous changes.
Journal ArticleDOI
Optical coherence tomography angiography of the peripapillary retina in glaucoma
Liang Liu,Yali Jia,Hana L. Takusagawa,Alex D. Pechauer,Beth Edmunds,Lorinna Lombardi,Ellen Davis,John C. Morrison,David Huang +8 more
TL;DR: Using OCT angiography, reduced peripapillary retinal perfusion in glaucomatous eyes can be visualized as focal defects and quantified as perIPapillary flow index and peripAPillary vessel density, with high repeatability and reproducibility.
Journal ArticleDOI
Quantitative OCT angiography of optic nerve head blood flow
Yali Jia,John C. Morrison,Jason Tokayer,Ou Tan,Lorinna Lombardi,Bernhard Baumann,Chen D. Lu,WooJhon Choi,James G. Fujimoto,David Huang +9 more
TL;DR: OCT angiography can detect the abnormalities of ONH perfusion and has the potential to reveal the ONH blood flow mechanism related to glaucoma, a pilot study indicates.
References
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Journal ArticleDOI
Shear dependence of effective cell volume as a determinant of blood viscosity.
TL;DR: The viscosity of suspensions of human erythrocytes was measured over a wide range of shear rates, and the macrorheological data were correlated with the micror heological behavior of ery throatcytes and rigid particles.
Journal ArticleDOI
Studies of factors involved in the production of low tension glaucoma.
TL;DR: The low tension glaucoma group had a significantly higher rate of hemodynamic crises, low systemic blood pressure, and low ophthalmic blood pressure than the ocular hypertensive group.
Journal Article
Distribution of axonal transport blockade by acute intraocular pressure elevation in the primate optic nerve head.
TL;DR: The distribution of short-term transport blockade over the entire nerve head corresponds to the diffuse damage of acute glaucoma, but the pattern hints at the preference for damage near the poles of the disk seen in chronic glau coma.
Journal ArticleDOI
Investigations into a vascular etiology for low-tension glaucoma.
TL;DR: This study does not support the concept of a generalized vascular etiology, either of an atheromatous or hyperviscous nature, for the genesis of low-tension glaucoma.
Journal ArticleDOI
Fluorescein angiographic defects of the optic disc in glaucoma.
TL;DR: The filling defects in open-angle glaucoma appear to be specific, indicating that the blood supply to the anterior portion of the optic nerve is involved, as in ischemic optic neuropathy.