Journal ArticleDOI
Optical density of human macular pigment.
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The results indicate higher density values for wavelengths on the long wavelength side of the absorption maximum, compared to the standard absorbance curve (Wyszecki and Stiles, 1967), and the mean density is higher than that previously reported.About:
This article is published in Vision Research.The article was published on 1987-01-01. It has received 129 citations till now.read more
Citations
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The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration
TL;DR: The concept that AMD can be attributed to cumulative oxidative stress is enticing, but remains unproven, and the effect of nutritional antioxidant supplements on the onset and natural course of age-related macular disease is currently being evaluated.
Journal Article
Analysis of the macular pigment by HPLC: retinal distribution and age study.
TL;DR: In individual retinas, the lutein:zeaxanthin ratio increased from an average of approximately 1:2.4 in the central 0-0.25 mm to over 2:1 in the periphery (8.7-12.2 mm), and the variation in this ratio with eccentricity was linearly correlated with the corresponding rod:cone ratio.
Journal ArticleDOI
Distribution of Lutein and Zeaxanthin Stereoisomers in the Human Retina
Richard A. Bone,John T. Landrum,Larry M. Friedes,Christina M. Gomez,Mark D. Kilburn,Eugenio Menendez,Ivonne Vidal,Weili Wang +7 more
TL;DR: It is proposed that lutein and zeaxanthin are transported into an individual's retina in the same proportions found in his or her blood serum, by a mechanism which is less developed in infants than adults.
Journal Article
Carotenoids in the human macula and whole retina.
TL;DR: The method presented in this study will facilitate quantitative investigations of the association between carotenoid levels and health and disease of the retina, and some older individuals show very high whole retinaCarotenoids have been proposed to be potent antioxidants, protecting membrane lipids from toxic peroxidation reactions.
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Photochemical damage of the retina.
TL;DR: This work has suggested that blue light may play a role in the pathogenesis of age-related macular degeneration, and laboratory studies have suggested that photochemical damage includes oxidative events.
References
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Journal Article
The macular pigment. II. Spatial distribution in primate retinas.
TL;DR: The spatial density distribution of macular pigment in primate retinas was described by two-wavelength microdensitometry of retinal sections, with the major axis of absorption oriented tangential to a circle centered on the fovea consistent with commonly accepted explanations of Haidinger's brushes.
Journal ArticleDOI
Preliminary identification of the human macular pigment.
TL;DR: Chromatograms of retinal extracts, obtained by HPLC on three different stationary phases, were found to match those obtained with mixtures of lutein and zeaxanthin standards.
Journal Article
The Macular Pigment. I. Absorbance Spectra, Localization, and Discrimination from Other Yellow Pigments in Primate Retinas
TL;DR: The nonbleaching yellow pigments of the primate fovea were studied by microspectrophotometry (MSP).