Journal ArticleDOI
Orbital immunoglobulin-G4-related disease: case series and literature review.
Kaustubh Mulay,Kaustubh Mulay,Ekta Aggarwal,Mehul Jariwala,Santosh G Honavar,Santosh G Honavar +5 more
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TLDR
It is reported that three cases of IgG4‐RD are reported and the literature extensively discussing various aspects of this novel entity are reviewed, including prognosis and pattern of tissue involvement.Citations
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IgG4-Related Ophthalmic Disease: Pooling of Published Cases and Literature Review
TL;DR: The demographic, clinical, histological, and treatment data for 172 published cases of biopsy-confirmed IgG4-ROD are presented, accompanied by a review of the relevant literature.
Journal ArticleDOI
Fibrosis, gene expression and orbital inflammatory disease
James T. Rosenbaum,Dongseok Choi,David J. Wilson,Hans E. Grossniklaus,Christina A. Harrington,Roger A. Dailey,John D. Ng,Eric A. Steele,Craig N. Czyz,Jill A. Foster,David T. Tse,Chris Alabiad,Sander R. Dubovy,Prashant K. Parekh,Gerald J. Harris,Michael Kazim,Payal J. Patel,Valerie A. White,Peter J. Dolman,Deepak P. Edward,Hind M. Alkatan,Hailah Al Hussain,Dinesh Selva,Patrick Yeatts,Bobby S. Korn,Don O. Kikkawa,Patrick Stauffer,Stephen R. Planck +27 more
TL;DR: A pathologist's recognition of fibrosis in orbital tissue correlates well with increased expression of transcripts that are considered essential in fibrosis, and many transcripts implicated in orbital fibrosis have been previously implicated in pulmonary fibrosis.
Journal ArticleDOI
IgG4-related dacryoadenitis evolving into an extra-nodal, marginal zone B-cell lymphoma (EMZL): a tale of two lacrimal glands.
Kaustubh Mulay,Ekta Aggarwal +1 more
Journal ArticleDOI
Ophthalmic immunoglobulin G4-related disease IgG4-RD Current concepts.
Kaustubh Mulay,Mark R. Wick +1 more
TL;DR: Although most cases respond well to therapy with glucocorticoids, refractoriness to treatment and relapses are common and necessitate the use of additional immunotherapy in such patients.
Journal ArticleDOI
Clinicopathologic features of orbital immunoglobulin G4-related disease (IgG4-RD): a case series and literature review
TL;DR: Orbital IgG4-RD is a distinct clinicopathologic entity requiring increased awareness and needs to be differentiated from other orbital lymphoproliferative lesions.
References
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Journal ArticleDOI
Lymphoplasmacytic sclerosing pancreatitis is a pancreatic lesion of IgG4-related systemic disease.
Journal ArticleDOI
Orbital IgG4-Related Disease: Clinical Features and Diagnosis
Toshinobu Kubota,Suzuko Moritani +1 more
TL;DR: Orbital IgG4-related disease must be differentiated from idiopathic orbital inflammation and ocular adnexal marginal zone B-cell lymphoma to ensure appropriate and effective treatment.
Journal ArticleDOI
Ocular adnexal marginal zone B cell lymphoma infiltrated by IgG4-positive plasma cells
TL;DR: It is suggested that ocular adnexal MZBLs with IgG4-positive plasma cells have unique histological and serological characteristics that overlap those of ocularAdnexal IgG 4-related lymphoplasmacytic infiltrative disorder and systemic conditions.
Journal ArticleDOI
Clinical features of a new disease concept, IgG4-related thyroiditis.
T. Watanabe,Masafumi Maruyama,Toshiro Ito,Yasunari Fujinaga,Yayoi Ozaki,Ryou Kodama,Takashi Muraki,Hideaki Hamano,Norikazu Arakura,Masumi Kadoya,Satoko Suzuki,Mitsuhisa Komatsu,Hisashi Shimojo,Kenji Notohara,M Uchida,Shigeyuki Kawa +15 more
TL;DR: Thyroid lesions associated with hypothyroidism can be considered as a new disease termed IgG4-related thyroiditis and awareness of this condition should lead to appropriate corticosteroid treatment that may prevent progression to a fibrous state.
Journal ArticleDOI
Clinical Aspects of IgG4-Related Orbital Inflammation in a Case Series of Ocular Adnexal Lymphoproliferative Disorders.
Masayuki Takahira,Yoshiaki Ozawa,Mitsuhiro Kawano,Yoh Zen,Shoko Hamaoka,Kazunori Yamada,Kazuhisa Sugiyama +6 more
TL;DR: Based on this study (26%) and another report (33%), it is likely that nearly a quarter of orbital LPD are IgG4-ROI, which is an important differential diagnosis for lymphoproliferative disorders.
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