Journal ArticleDOI
Orbital lymphoid neoplasms: a clinicopathologic study of 60 patients.
TLDR
The degree of cytologic differentiation appears to be the single most important factor for determining the prognosis of patients with orbital lymphoid neoplasms.Abstract:
Sixty cases of orbital lymphoid neoplasms originally accessioned as malignant lymphomas were analyzed histopathologically and the follow-up data evaluated separately for each category as follows: inflammatory pseudo-tumor, 5; reactive lymphoid hyperplasia, 8; atypical lymphoid hyperplasia, 7; and malignant lymphocytic lymphoma (classified according to Rappaport), 40. Significant clinical differences were not observed among these patients, suggesting that the lesions must be distinguished by histologic rather than clinical criteria. Systematic application of the histologic criteria discussed here improved diagnostic accuracy and our ability to predict clinical outcome as substantiated by follow-up data. Two of 13 patients (15%) with benign pseudo-lymphomas, 2 of 7 patients (29%) with atypical lymphoid hyperplasia, 2 of 8 patients (25%) with well differentiated lymphocytic lymphomas, and 22 of 32 patients (68%) with less differentiated lymphocytic lymphomas either had or later developed systemic lymphomas. Thus, the degree of cytologic differentiation appears to be the single most important factor for determining the prognosis of patients with orbital lymphoid neoplasms.read more
Citations
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Journal ArticleDOI
Lymphoproliferative lesions of the ocular adnexa: Analysis of 112 cases
Sarah E. Coupland,Lothar Krause,Henri Jacques Delecluse,Ioannis Anagnostopoulos,Hans Dieter Foss,Michael Hummel,Norbert Bornfeld,William R. Lee,Harald Stein +8 more
TL;DR: The REAL classification is suitable for the subdivision of the ocular adnexal lymphomas, and the MIB-1 proliferation rate and p53 positivity may aid the prediction of disease stage and disease progression, whereas PCR can support the diagnosis and reduce the number of histologically indeterminate lesions.
Journal ArticleDOI
Lymphoid hyperplasia and malignant lymphoma occurring in the ocular adnexa (orbit, conjunctiva, and eyelids): A prospective multiparametric analysis of 108 cases during 1977 to 1987
Daniel M. Knowles,Daniel M. Knowles,Frederick A. Jakobiec,Frederick A. Jakobiec,Lois McNally,Lois McNally,Jerome S. Burke,Jerome S. Burke +7 more
TL;DR: Eighty-six percent of patients presenting with a unilateral or bilateral clinical stage lE ocular adnexal lymphoid proliferation, regardless of the histopathology or the immunophenotype, had a benign indolent clinical course and failed to develop ocular or extra-ocular lymphoma during a median follow-up period of 51 months.
Journal ArticleDOI
What is orbital pseudotumor
TL;DR: In this article, the authors reviewed the literature in order to delineate the clinicopathologic definition of orbital pseudotumors, also called idiopathic nonspecific orbital inflammation.
Journal ArticleDOI
Ocular adnexal lymphoma. A clinicopathologic study with identification of lymphomas of mucosa-associated lymphoid tissue type
TL;DR: Ocular adnexal lymphomas are B-cell tumors that develop in older adults, predominantly among women and a high proportion of them have MALT characteristics, and primary orbital lymphomas have a favorable prognosis.
Journal ArticleDOI
Primary non-Hodgkin's lymphoma and pseudolymphoma of lung: A study of 161 patients
TL;DR: Neither histologic subtype among the "small cell" lymphoid lymphomas nor the presence of regional node involvement was prognostically significant, but pleural effusion on the initial chest radiograph was a significant predictor of both recurrence and mortality.
References
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Journal ArticleDOI
Occurrence and prognosis of extranodal lymphomas.
TL;DR: The prognosis of patients with extranodal lymphomas is compared with that for “all cancers” of the same site, and the lymphoma patients appear to fare appreciably better when the site of origin is stomach, lung, or tonsil.
Journal ArticleDOI
Immunologic characterization of human malignant lymphomas
TL;DR: Preliminary results of retrospective morphological studies indicate that over 70% of non‐Hodgkin's lymphomas involve cleaved or noncleaved follicular center cell (FCC) or B cell types, and nodularity is observed only with FCC types.
Journal ArticleDOI
The monoclonality of human B-cell lymphomas.
TL;DR: It is anticipated that the approach described here will be useful in the diagnosis of lymphoma, differentiating it from reactive lymphoid hyperplasia by the demostration of monoclonality, and should provide a sensitive and reliable tool for investigating the immunobiology of human lymphoma.
Journal ArticleDOI
Malignant lymphomas of the thyroid. A clinical pathologic study of 35 patients including ultrastructural observations
TL;DR: Patients under age 65, without local soft tissue extension or regional lymph node involvement, and with stage I disease survived the longest; a nodular histologic pattern also appeared to favorably influence the prognosis and improved staging procedures and newer modes of therapy appear essential.
Journal ArticleDOI
Morphological studies of 84 untreated patients subjected to laparotomy for the staging of non‐Hodgkin's lymphomas
Hun Kim,Ronald F. Dorfman +1 more
TL;DR: Evaluation of stage of the disease alone does not suffice in assessing response to therapy and long‐term survival, in view of the poor prognosis of diffuse histiocytic lymphomas despite their initial localized involvement, and the importance of differentiating lymphomas according to cytologic type and architectural pattern is emphasized.