Journal ArticleDOI
Oxidation of manganous pyrophosphate by superoxide radicals and illuminated spinach chloroplasts.
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TLDR
It is proposed that the O 2 − generated as the sole initial step of the Mehler reaction oxidized Mn 2+ -pyrophosphate, and the role of free manganese in chloroplasts is discussed.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 1976-06-01. It has received 96 citations till now. The article focuses on the topics: Pyrophosphate & Mehler reaction.read more
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Superoxide Radical and Superoxide Dismutases
TL;DR: O2- oxidizes the [4Fe-4S] clusters of dehydratases, such as aconitase, causing-inactivation and release of Fe(II), which may then reduce H2O2 to OH- +OH..
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Generation of Superoxide Radical during Autoxidation of Hydroxylamine and an Assay for Superoxide Dismutase
TL;DR: Hydrogen peroxide stimulated the autoxidation and superoxide dismutase inhibited the hydrogen peroxide-induced oxidation, results which suggest the participation of hydrogenperoxide in autoxidated and in the generation of superoxide radical.
Journal ArticleDOI
Carbohydrate metabolism in lactic acid bacteria.
TL;DR: An overview of the following topics is given: main pathways of homo- and heterofermentation of hexoses, i.e. glycolysis, bifidus pathway, 6-phosphogluconate pathway; uptake and dissimilation of lactose (tagatose pathway); fermentation of pentoses and pentitols; alternative fates of pyruvate.
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The biology and pathology of oxygen radicals.
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: Production of O2- by activated neutrophils is clinically significant, since it is an important component of the bactericidal actions of these cells and the inflammatory process, and exerts an anti-inflammatory action that may be useful in managing inflammations.
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The scavenging of superoxide radical by manganous complexes: In vitro☆
TL;DR: In this paper, the authors examined the mechanisms by which Mn catalytically scavenges O2−, both in the xanthine oxidase/cytochrome c SOD assay and in a number of in vitro systems relevant to the in vivo situation.
References
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Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.
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Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels☆
TL;DR: The staining procedure for localizing superoxide dismutase on polyacrylamide electrophoretograms has been applied to extracts obtained from a variety of sources and could thus be assayed either in crude extracts or in purified protein fractions.
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Photoperoxidation in isolated chloroplasts. II. Role of electron transfer.
Robert L. Heath,Lester Packer +1 more
TL;DR: The results suggest that at high light intensities, overloading of the chlorophyll collection system results in energy being channeled into destructive cyclic peroxidation processes involving the membrane fatty acids.
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Evidence that Peroxidation of Lysosomal Membranes Is Initiated by Hydroxyl Free Radicals Produced during Flavin Enzyme Activity
TL;DR: It was demonstrated that the superoxide free radical per se was not the agent causing lysis, and evidence is presented that the free radical causing the lysis of the lysosomes is the hydroxyl free radical (OH·).
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Oxidation of ascorbic acid with superoxide anion generated by the xanthine-xanthine oxidase system
TL;DR: A function of ascorbic acid as a defense against O2− is presented and a kinetic analysis of the inhibition of this reaction by superoxide dismutase shows that the second-order rate constant for the reaction between ascorBic acid and O2 − at pH 7.4 was estimated to be 2.7 × 105 M−1 sec−1.
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Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more