Open AccessJournal Article
Oxygen poisoning in mice. Ultrastructural and surfactant studies during exposure and recovery.
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This article is published in Archives of pathology.The article was published on 1970-11-01 and is currently open access. It has received 82 citations till now. The article focuses on the topics: Pulmonary surfactant & Histocytochemistry.read more
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Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis.
TL;DR: It is suggested that severe injury and retarded repair of the alveolar epithelium disturbs normal epithelial-fibroblast interactions and is sufficient to promote the fibrotic process.
Journal ArticleDOI
Interleukin-6-induced protection in hyperoxic acute lung injury.
Nicholas S. Ward,Aaron B. Waxman,Robert J. Homer,Lin L. Mantell,Oskar Einarsson,YuFen Du,Jack A. Elias +6 more
TL;DR: It is demonstrated that IL-6 markedly diminishes hyperoxic lung injury and that this protection is associated with a marked diminution in hyperoxia-induced cell death and DNA fragmentation.
Journal ArticleDOI
IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury
Jonathan Corne,Geoffrey L. Chupp,Chun Guen Lee,Robert J. Homer,Zhou Zhu,Qingsheng Chen,Bing Ma,Yuefen Du,Francoise Roux,John R. McArdle,Aaron B. Waxman,Aaron B. Waxman,Jack A. Elias +12 more
TL;DR: IL-13 has protective effects in hyperoxic acute lung injury, and it is demonstrated that IL-13, alone and in combination with 100% (2), stimulates pulmonary VEGF accumulation, that this stimulation is isoform-specific, and that the protective effects of IL- 13 are mediated, in part, by VEGf.
Journal ArticleDOI
Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.
Aaron B. Waxman,Oskar Einarsson,Tamas Seres,R. G. Knickelbein,Joseph B. Warshaw,Richard B. Johnston,Robert J. Homer,Jack A. Elias +7 more
TL;DR: It is demonstrated that IL-11 markedly diminishes hyperoxic lung injury and this protection is associated with small changes in lung antioxidants, diminished hyperoxia-induced IL-1 and TNF production, and markedly suppressed hyperoxIA-induced DNA fragmentation.
Journal ArticleDOI
Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development
Min Yee,Peter F. Vitiello,Jason M. Roper,Rhonda J. Staversky,Terry W. Wright,Sharon A. McGrath-Morrow,William M. Maniscalco,Jacob N. Finkelstein,Michael A. O'Reilly +8 more
TL;DR: The data suggest that perinatal hyperoxia adversely affects alveolar development by disrupting the proper timing of type II cell proliferation and differentiation into type I cells.
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