Open AccessJournal Article
The type 2 cell as progenitor of alveolar epithelial regeneration. A cytodynamic study in mice after exposure to oxygen.
I Y Adamson,Drummond H. Bowden +1 more
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This article is published in Laboratory Investigation.The article was published on 1974-01-01 and is currently open access. It has received 698 citations till now. The article focuses on the topics: Regeneration (biology) & Progenitor.read more
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The acute respiratory distress syndrome
TL;DR: An overview of the definitions, clinical features, and epidemiology of the acute respiratory distress syndrome is provided and advances in the areas of pathogenesis, resolution, and treatment are discussed.
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The acute respiratory distress syndrome.
TL;DR: Progress has been made in understanding the mechanisms responsible for the pathogenesis and the resolution of lung injury, including the contribution of environmental and genetic factors, and on developing novel therapeutics that can facilitate and enhance lung repair.
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Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
Kevin K. Kim,Matthias C. Kugler,Paul J. Wolters,Liliane Robillard,Michael G. Galvez,Alexis N. Brumwell,Dean Sheppard,Harold A. Chapman +7 more
TL;DR: Alveolar epithelial cells are revealed as progenitors for fibroblasts in vivo and implicate the provisional extracellular matrix as a key regulator of epithelial transdifferentiation during fibrogenesis.
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TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease
Brigham C. Willis,Zea Borok +1 more
TL;DR: It is hoped that this review will stimulate further consideration of the cellular mechanisms of fibrogenesis in the lung and especially the role of the epithelium in this process, potentially leading to innovative avenues of investigation and treatment.
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Alveolar progenitor and stem cells in lung development, renewal and cancer
TL;DR: There is a switch after birth, when AT2 cells function as stem cells that contribute to alveolar renewal, repair and cancer, and it is proposed that local signals regulate AT2 stem-cell activity.