Journal ArticleDOI
Paraoxonase protects against chlorpyrifos toxicity in mice
Reads0
Chats0
TLDR
It is indicated that exogenous paraoxonase offers significant protection against CPS toxicity when administered both before and after the organophosphate, suggesting that it may be considered as a potential additional treatment of organoph phosphate poisoning.About:
This article is published in Toxicology Letters.The article was published on 1995-04-01. It has received 175 citations till now. The article focuses on the topics: Paraoxonase & Acute toxicity.read more
Citations
More filters
Journal ArticleDOI
Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis
Diana M. Shih,Lingjie Gu,Yu Rong Xia,Mohamad Navab,Wan Fen Li,Susan Hama,Lawrence W. Castellani,Clement E. Furlong,Lucio G. Costa,Alan M. Fogelman,Aldons J. Lusis +10 more
TL;DR: When fed on a high-fat, high-cholesterol diet, PON1 -null mice were more susceptible to atherosclerosis than their wild-type littermates.
Book ChapterDOI
Organophosphates⧸Nerve Agent Poisoning: Mechanism of Action, Diagnosis, Prophylaxis, And Treatment
TL;DR: The diagnosis of OP/nerve agent poisoning is based on anamnesis, the clinical status of the intoxicated organism, and on cholinesterase determination in the blood, where AChE in the red blood cell is more diagnostically important than BuChE activity in the plasma.
Journal ArticleDOI
The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin
Holly G. Davies,Rebecca J. Richter,Matthew C. Keifer,Clarence A. Broomfield,Jason Sowalla,Clement E. Furlong +5 more
TL;DR: A simple enzyme analysis is reported that provides a clear resolution of PON1 genotypes and phenotypes allowing for a reasonable assessment of an individual's probable susceptibility or resistance to a given OR, extending earlier studies on this system.
Journal ArticleDOI
Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment.
David L. Eaton,Robert B. Daroff,Herman Autrup,James W. Bridges,Patricia A. Buffler,Lucio G. Costa,Joseph T. Coyle,Guy M. McKhann,William C. Mobley,Lynn Nadel,Diether Neubert,Rolf Schulte-Hermann,Peter S. Spencer +12 more
TL;DR: The results of this review demonstrate that the use of urinary 3,5,6-trichlorpyridinol (TCPy), a metabolite of chlorpyrifos as a biomarker of nonoccupational exposure is problematic and may overestimate non Occupational exposures to chlorparyifos by 10-to 20-fold because of the widespread presence of both TCPy and chlorp Pyrifos-methyl in the food supply.
Journal ArticleDOI
Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression.
Victoria H. Brophy,Rachel L. Jampsa,James B. Clendenning,Laura A. McKinstry,Gail P. Jarvik,Clement E. Furlong +5 more
TL;DR: The results presented here indicate that the L55M effect of lowered activity is not due to the amino acid change but is, rather, largely due to linkage disequilibrium with the -108 regulatory-region polymorphism.
References
More filters
Journal ArticleDOI
A new and rapid colorimetric determination of acetylcholinesterase activity.
TL;DR: A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented.
Book
Practical statistics for medical research
TL;DR: Practical Statistics for Medical Research is a problem-based text for medical researchers, medical students, and others in the medical arena who need to use statistics but have no specialized mathematics background.
Journal ArticleDOI
The molecular basis of the human serum paraoxonase activity polymorphism.
Richard Humbert,David A. Adler,Christine M. Disteche,Christopher Hassett,Curtis J. Omiecinski,Clement E. Furlong +5 more
TL;DR: It is demonstrated that arginine at position 192 specifies high activity PON whereas a glutamine specifies the low activity variant, and that PON maps to chromosome 7q21–22, proximal to the cystic fibrosis gene, in agreement with previous genetic linkage studies.
Journal Article
The human serum paraoxonase/arylesterase polymorphism.
H W Eckerson,C M Wyte,B N La Du +2 more
TL;DR: It is postulate that a single serum enzyme, with both paraox onase and arylesterase activity, exists in two different isozymic forms with qualitatively different properties, and that paraoxon is a "discriminating" substrate (having a polymorphic distribution of activity) and phenylacetate is a 'nondiscriminating' substrate for the two isozymes.