Pathophysiologic Basis and Diagnostic Approaches for Ischemia With Non-obstructive Coronary Arteries: A Literature Review
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TLDR
The pathophysiologic basis and contemporary and novel diagnostic approaches for INOCA are discussed to construct a better understanding of InOCA evaluation.Abstract:
Ischemia with non-obstructive coronary arteries (INOCA) has gained increasing attention due to its high prevalence, atypical clinical presentations, difficult diagnostic procedures, and poor prognosis. There are two endotypes of INOCA—one is coronary microvascular dysfunction and the other is vasospastic angina. Diagnosis of INOCA lies in evaluating coronary flow reserve, microcirculatory resistance, and vasoreactivity, which is usually obtained via invasive coronary interventional techniques. Non-invasive diagnostic approaches such as echocardiography, single-photon emission computed tomography, cardiac positron emission tomography, and cardiac magnetic resonance imaging are also valuable for assessing coronary blood flow. Some new techniques (e.g., continuous thermodilution and angiography-derived quantitative flow reserve) have been investigated to assist the diagnosis of INOCA. In this review, we aimed to discuss the pathophysiologic basis and contemporary and novel diagnostic approaches for INOCA, to construct a better understanding of INOCA evaluation.read more
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Journal ArticleDOI
Ischemia with No Obstructive Arteries (INOCA): A review of the prevalence, diagnosis and management.
B. Hansen,Jessica N. Holtzman,Caroline Juszczynski,Najah Khan,Gurleen Kaur,Bh. V. K. Praveen Varma,Martha Gulati +6 more
TL;DR: Ischemia with no obstructive arteries (INOCA) as mentioned in this paper is defined as patients with angiographic evidence of ischemia but no obstructionive coronary artery disease (CAD) at coronary angiography.
Journal ArticleDOI
Features of coronary pathology and its relationship with myocardial fibrosis markers in patients with resistant hypertension
Valeria Lichikaki,Victor Mordovin,A. Falkovskaya,I. V. Zyubanova,M. Manukyan,E. Solonskaya,A. Vtorushina,S. Khunkhinova +7 more
TL;DR: In this article , the severity of coronary atherosclerosis and its association with biochemical markers of fibrosis in patients with coronary artery disease (CAD) and resistant hypertension (RHT) were evaluated.
Journal ArticleDOI
Epidemiological and quality of life analysis of patients with ANOCA
Ana Carolina de Souza,Mário Augusto Cray da Costa,Elise Souza dos Santos Reis,Luiz Henrique Vargas de Andrade,Tiago Dimas Antunes de Souza +4 more
TL;DR: In this paper , an observational cross-sectional study was conducted by applying questionnaires (SAQ-7 and SF-36) in patients undergoing catheterization in a single hospital from September 2021 to June 2022, and who did not have significant coronary artery obstructions (≥50%).
Journal ArticleDOI
Improved detection of coronary artery disease by CZT regional coronary blood flow evaluation
Ronaldo de Souza Leão Lima,A. J. C. Bezerra,Mônica Vieira Athanazio de Andrade,Capizzi Domenico,Andrea De Lorenzo +4 more
TL;DR: In this paper , the authors compared myocardial perfusion SPECT (MPS) with or without MFR evaluation for the detection of obstructive coronary artery disease (CAD).
Journal ArticleDOI
Ischemia with Nonobstructive Coronary Artery Disease and Atrial Cardiomyopathy—Two Sides of the Same Story?
Irina Afrasanie,Iulian Theodor Matei,Sabina Andreea Leancă,Adriana Chetran,Alexandru Dan Costache,Vlad-Adrian Afrăsânie,Bianca-Ana Dmour,D Crisu,Minerva Codruta Badescu,Lacramioara Ionela Serban,Irina-Iuliana Costache +10 more
TL;DR: In this paper , a review of the existing body of evidence, analyzing the existing evidence, offering further insight into the mechanisms of CMD and atrial cardiomyopathy, and discussing potential therapeutic strategies.
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