Journal ArticleDOI
Penicillin therapy in icteric leptospirosis.
TLDR
It is concluded that penicillin has little effect on clinical outcome in icteric leptospirosis.Abstract:
A prospective, controlled randomized study of penicillin therapy in icteric human leptospirosis was carried out between 1 October 1983 and 31 December 1986. Thirty-eight patients received intravenous crystalline penicillin for 5 days, while 41 assigned to a control group received intravenous fluids only. A comparison of the results of laboratory tests made on the day of admission revealed no significant differences between the 2 groups. There was no significant difference in time for defervescence, return of biochemical parameters to normal, incidence of iritis, or mortality in the 2 groups. Three patients (7.3%) in the control group and 1 patient (2.6%) in the treatment group died. The overall mortality rate was 5.9%. Leptospira were recovered from urine cultures in 6 control patients but from none of the treated patients' post-treatment cultures. We conclude that penicillin has little effect on clinical outcome in icteric leptospirosis.read more
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Journal ArticleDOI
Leptospirosis: a zoonotic disease of global importance
Ajay R. Bharti,Jarlath E. Nally,Jessica N. Ricaldi,Michael A. Matthias,Monica M. Diaz,Michael A. Lovett,Paul N. Levett,Robert H. Gilman,Michael R. Willig,Eduardo Gotuzzo,Joseph M. Vinetz +10 more
TL;DR: The completion of the genome sequence of Leptospira interrogans serovar lai, and other continuing leptospiral genome sequencing projects, promise to guide future work on the disease.
Journal ArticleDOI
The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America
Gary P. Wormser,Raymond J. Dattwyler,Eugene D. Shapiro,John J. Halperin,Allen C. Steere,Mark S. Klempner,Peter J. Krause,Johan S. Bakken,Franc Strle,Gerold Stanek,Linda K. Bockenstedt,Durland Fish,J. Stephen Dumler,Robert B. Nadelman +13 more
TL;DR: These updated guidelines replace the previous treatment guidelines published in 2000 and list the doses and durations of antimicrobial therapy recommended for treatment and prevention of Lyme disease and provide a partial list of therapies to be avoided.
Book ChapterDOI
Leptospirosis in Humans
David A. Haake,Paul N. Levett +1 more
TL;DR: Data emerging from prospective surveillance studies suggest that most human leptospiral infections in endemic areas are mild or asymptomatic, and patients progressing to multisystem organ failure have widespread hematogenous dissemination of pathogens.
Journal ArticleDOI
Overview of the epidemiology, microbiology, and pathogenesis of Leptospira spp. in humans
TL;DR: Leptospirosis is probably the world's most widespread zoonosis and it remains underdiagnosed largely due to the broad spectrum of signs and symptoms attributable to this spirochetal pathogen.
Journal ArticleDOI
Usefulness of Serologic Analysis as a Predictor of the Infecting Serovar in Patients with Severe Leptospirosis
TL;DR: Serologic analysis appeared to be of little value for the identification of the infecting serovar in individual cases of leptospirosis in humans, and presumptive serogroup reactivity data should be used only to gain a broad idea of the serogroups present at the population level.