Perfusion alters stiffness of deep gray matter.
Stefan Hetzer,Patric Birr,Andreas Fehlner,Sebastian Hirsch,Florian Dittmann,Eric Barnhill,Jürgen Braun,Ingolf Sack +7 more
TLDR
The distinct mechano-vascular properties of striatum tissue, as compared to the rest of DGM, may reflect elevated perfusion pressure, which could explain the well-known susceptibility of the putamen to hemorrhages.Abstract:
Viscoelastic properties of the brain reflect tissue architecture at multiple length scales. However, little is known about the relation between vital tissue functions, such as perfusion, and the ma...read more
Citations
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MR elastography of the brain and its application in neurological diseases.
TL;DR: Magnetic resonance elastography can reliably measure global and regional stiffness in the brain in vivo and is a promising tool for the preoperative assessment of intracranial tumors, as it can measure both tumor consistency and adherence to surrounding tissues.
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High-resolution magnetic resonance elastography reveals differences in subcortical gray matter viscoelasticity between young and healthy older adults.
Lucy V Hiscox,Curtis L. Johnson,Matthew D. J. McGarry,Michael Perrins,Aimee Littlejohn,Edwin J R van Beek,Neil Roberts,John M. Starr +7 more
TL;DR: Evaluated global and regional MRE parameter differences between young and healthy older adults and to assess whether MRE measures provide additive value over volumetric magnetic resonance imaging measurements support the use of MRE as a novel imaging biomarker for characterizing age-related differences to neural tissue not captured byvolumetric imaging alone.
Journal ArticleDOI
Stiffness reconstruction methods for MR elastography.
TL;DR: Many current MRE reconstruction methods are reviewed, including inversion type, underlying assumptions, and their use in human and animal studies, and future directions, such as alternative material assumptions, are also discussed.
Journal ArticleDOI
Glial Tissue Mechanics and Mechanosensing by Glial Cells.
Katarzyna Pogoda,Paul A. Janmey +1 more
TL;DR: A multi-level approach from whole organ rheology to single cell mechanics is needed to understand the physical aspects of human brain function and its pathologies.
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Targeting Cerebral Small Vessel Disease With MRI
TL;DR: Treatment options are restricted to preventive risk management and better understanding of both the pathogenesis of SVD and the subsequent pathophysiological mechanism by which SVD leads to macroscopic brain tissue damage could stimulate the development of more effective treatments.
References
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Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain
Nathalie Tzourio-Mazoyer,B. Landeau,D. Papathanassiou,Fabrice Crivello,Octave Etard,Nicolas Delcroix,Bernard Mazoyer,Marc Joliot +7 more
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Oliver D. Howes,Shitij Kapur +1 more
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Magnetic resonance elastography by direct visualization of propagating acoustic strain waves
Raja Muthupillai,D. J. Lomas,Phillip J. Rossman,James F. Greenleaf,Armando Manduca,Richard L. Ehman +5 more
TL;DR: The results indicate that displacement patterns corresponding to cyclic displacements smaller than 200 nanometers can be measured and suggest the feasibility of a medical imaging technique for delineating elasticity and other mechanical properties of tissue.