Journal ArticleDOI
Periodicity of speech in Parkinsonism.
C. Mawdsley,C. V. Gamsu +1 more
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TLDR
The term itself is difficult of definition, but it is generally thought to imply a delay in initiation of movement combined with slowness and restriction in amplitude of movements once initiated.Abstract:
IMPAIRMENT of speech, leading sometimes to unintelligibility, was recognized by Parkinson1 to be part of the disease which now bears his name. Reduced voice volume, dysarthria and prosodic monotony are common manifestations of Parkinsonism2 and are generally attributed to hypokinesis, a cardinal feature of the disease, the physiological basis of which is ill understood. The term itself is difficult of definition, but it is generally thought to imply a delay in initiation of movement combined with slowness and restriction in amplitude of movements once initiated.read more
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Treatments for dysarthria in Parkinson's disease
Serge Pinto,Canan Ozsancak,Elina Tripoliti,Stéphane Thobois,Patricia Limousin-Dowsey,Pascal Auzou +5 more
TL;DR: Management of dysarthria is still challenging for the clinician and should be discussed with the patient, and use of levodopa to replenish dopamine concentrations in the striatum seems to improve articulation, voice quality and pitch variation, although some studies show no change in phonatory parameters.
Journal ArticleDOI
Speech treatment for Parkinson's disease.
Marilyn Trail,Marilyn Trail,Cynthia Fox,Lorraine Olson Ramig,Lorraine Olson Ramig,Shimon Sapir,Julia Howard,Eugene C. Lai +7 more
TL;DR: The authors review the literature on the characteristics and features of speech and voice disorders in people with PD, the types of treatment techniques available, including medical, surgical, and behavioral therapies, and provide recommendations for the current efficacy of treatment interventions and directions of future research.
Journal ArticleDOI
Reflections of depression in acoustic measures of the patient’s speech
TL;DR: Clinical impressions are substantially related to acoustic parameters and temporal changes associated with depression appear to reflect the depressed state whereas prosodic features seem to reflect a depressed trait.
Journal ArticleDOI
Effects of speech therapy and pharmacologic and surgical treatments on voice and speech in Parkinson's disease: a review of the literature.
Geralyn M. Schulz,Megan K Grant +1 more
TL;DR: A review of different treatment approaches for persons with Parkinson's disease (PD) and the effects of these treatments on speech is presented in this paper, where speech therapy, pharmacological, and surgical treatment methods are compared.
Journal ArticleDOI
Molecular interactions of the junctional foot protein and dihydropyridine receptor in skeletal muscle triads.
TL;DR: A new model for the triad junction is proposed which combines the JFP with GAPDH and aldolase with a previously undetectedMr 95 K protein, an integral protein of the junctional domain of the SR terminal cisternae.
References
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Book
Biological Foundations of Language
TL;DR: The coming of language occurs at about the same age in every healthy child throughout the world as mentioned in this paper, strongly supporting the concept that genetically determined processes of maturation, rather than env...
Journal ArticleDOI
The Biological Foundations of Language
TL;DR: The coming of language occurs at about the same age in every healthy child throughout the world, strongly supporting the concept that genetically determined processes of maturation, rather than environs-based processes, are responsible for this development.
Journal ArticleDOI
[Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system].
H. Ehringer,Oleh Hornykiewicz +1 more
TL;DR: The distribution of noradrenaline and dopamine in human adult and newborn brains has been investigated in this paper, where the greatest amounts of dopamine were found in the hypothalamus, the central gray matter of the mesencephalon, the reticular formation and in the area postrema.
Book
An Essay on the Shaking Palsy
TL;DR: In this article, the authors present a conciliatory explanation for the present publication, in which, it is acknowledged, that mere conjecture takes the place of experiment; and, that analogy is the substitute for anatomical examination, the only sure foundation for pathological knowledge.