Patent
pH-sensitive, serum-stable liposomes
TLDR
In this article, a thermally-sensitive polymer with a pH-sensitive substituent was used to provide liposomes that are pH sensitive, yet are also stable in serum.Abstract:
This invention relates to the field of liposomes In particular, this invention provides novel liposomes that are pH-sensitive, yet are also stable in serum The liposomes are complexed with a molecule comprising a thermally-sensitive polymer showing lower critical solution temperature behavior in aqueous solutions, said thermally-sensitive polymer bearing a hydrophobic substituent and a pH sensitive substituent, wherein said hydrophobic substituent is less than 10 kD and which pH sensitive substituent remains ionizable following said covalent bonding to said thermally-sensitive polymer, and whose pH sensitive does not depend on cleavage of the covalent bond to said thermally-sensitive polymer The invention further relates to methods of conferring pH sensitivity upon liposomes by complexing the liposomes with such moleculesread more
Citations
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Patent
Amino acid lipids and uses thereof
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References
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Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH
Guohua Chen,Allan S. Hoffman +1 more
TL;DR: A polymer is described that undergoes marked solubility changes in water in response to temperature and/or pH changes and it is found that block copolymers, in which the temperature- and pH-sensitive units alternate along the chain, show similar behaviour.
Journal ArticleDOI
Sterically stabilized liposomes
Martin C. Woodle,Danilo D. Lasic +1 more
TL;DR: The structure-function relationship of PEG-derivatized phosphatidylethanolamine (PEG-PE) has been examined by measurement of blood lifetime and tissue distribution in both mice and rats and Steric stabilization has been proposed as a theoretical basis for the results.
Journal ArticleDOI
Effect of comonomer hydrophilicity and ionization on the lower critical solution temperature of N-isopropylacrylamide copolymers
TL;DR: In this paper, the authors investigated the mechanism of temperature-induced phase separation and the effect of comonomer content, hydrophilicity, and charge on the lower critical solution temperature.
Journal ArticleDOI
Volume‐phase transitions of ionized N‐isopropylacrylamide gels
TL;DR: In this article, the authors measured the equilibrium swelling curves of Nisopropylacrylamide (NIPA) gel and a series of its ionized counterparts as a function of temperature.
Journal ArticleDOI
Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle.
TL;DR: DNA complexes containing plasmid DNA, transferrin-polylysine conjugates, and polylysine-conjugated peptides derived from the N-terminal sequence of the influenza virus hemagglutinin subunit HA-2 are used for the transfer of luciferase or beta-galactosidase marker genes to K562 cells, HeLa cells, and BNL CL.2 hepatocytes.