Open AccessJournal Article
Pharmaceutical characteristics of brucine stealth liposomes
TLDR
As the antitumor durg delivery system, the in vitro characteristics of brucine stealth liposome are more satisfactory than the corresponding conventional liposomes.Abstract:
Objective To prepare brucine stealth liposomes and compare the in vitro characteristics with brucine conventional liposomes. Method Brucine stealth liposomes and conventional liposomes were both prepared by ammonium sulfate transmembrane gradients. The encapsulation efficiency, particle size, in vitro release profiles and stability were compared respectively. Result The encapsulation efficiency of brucine stealth liposomes and conventional liposomes were (80.7 +/- 0.5)%, and (80.5 +/- 0.3)%, respectively. The mean paricle sizes were 103.5 nm and 169. 4 nm, respectively. Whether rat plasma was added or not, the release rate and degree of brucine stealth liposomes were significantly lower than those of conventional liposomes. Brucine stealth liposomes were more stable than conventional liposomes. Conclusion As the antitumor durg delivery system, the in vitro characteristics of brucine stealth liposomes are more satisfactory than the corresponding conventional liposomes.read more
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Ammonium sulfate gradient loading of brucine into liposomes: effect of phospholipid composition on entrapment efficiency and physicochemical properties in vitro
TL;DR: Efficient encapsulation of brucine into the novel liposomes, their improved stability, and the price of phospholipids indicate that the novelliposomes may act as promising carriers for active alkaloids such as Brucine.
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Chemical constituents, pharmacological action, antitumor application, and toxicity of Strychnine Semen from Strychnons pierriana A.W.Hill.: A review.
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