In vitro and in vivo evaluation of novel NGR-modified liposomes containing brucine.
Shu Li,Xi-Peng Wang +1 more
TLDR
In vivo, NGR-brucine liposomes could significantly extend the bioavailability of brucine; however, there was no significant difference observed in the pharmacokinetic parameters betweenliposomes and NGR liposome after intravenous administration.Abstract:
In this study, a novel NGR (Asn-Gly-Arg) peptide-modified liposomal brucine was prepared by using spray-drying method. The surface morphology of the liposomes, encapsulation efficiency and particle size were investigated. The data showed that the addition of NGR did not produce any significant influence on brucine liposomes in terms of particle size or zeta potential. In addition, after 3 months of storage, no dramatic change such as visible aggregation, drug content changes or precipitation in the appearance of NGR-brucine liposomes occurred. The in vitro release results indicated that the release of brucine from NGR liposomes was similar to that of liposomes, demonstrating that the NGR modification did not affect brucine release. The in vitro drug-release kinetic model of NGR-brucine liposomes fitted well with the Weibull's equation. In vivo, NGR-brucine liposomes could significantly extend the bioavailability of brucine; however, there was no significant difference observed in the pharmacokinetic parameters between liposomes and NGR liposomes after intravenous administration. Antitumor activity results showed that NGR-modified liposomes exhibited less toxicity and much higher efficacy in HepG2-bearing mice compared with non-modified liposomes. The enhanced antitumor activity might have occurred because brucine was specifically recognized by NGR receptor on the surface of tumor cells, which enhanced the intracellular uptake of drugs.read more
Citations
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Stability and reactivity study of bio-molecules brucine and colchicine towards electrophile and nucleophile attacks: Insight from DFT and MD simulations
Y. Sheena Mary,Y. Shyma Mary,Stevan Armaković,Sanja J. Armaković,Rohitash Yadav,Ismail Celik,Pratap Mane,Brahmananda Chakraborty,Brahmananda Chakraborty +8 more
TL;DR: In this article, a set of molecular descriptors have been calculated and used in order to identify the most reactive parts of bioactive molecules, brucine (BRU) and colchicine (COL).
Journal ArticleDOI
Development, optimization, and evaluation of PEGylated brucine-loaded PLGA nanoparticles.
TL;DR: Significant reductions in tumor growth rate and mortality rate were observed for PEG PLGA NP formulations compared to both BRU solution and naked NPs.
Journal ArticleDOI
Development of docetaxel liposome surface modified with CD133 aptamers for lung cancer targeting.
TL;DR: In vitro antitumour activity and cytotoxicity study, CD133 aptamers modified DTX LP significantly decreased cell proliferation and improved the therapeutic efficiency and in vivo imaging result indicated that CD133-DTX LP had very good tumour targeting ability.
Journal ArticleDOI
Preparation, in vitro and in vivo evaluation of isoliquiritigenin-loaded TPGS modified proliposomes.
Jian Liu,Qilong Wang,Michael Adu-Frimpong,Qiuyu Wei,Yujiao Xie,Kangyi Zhang,Chunmei Wei,Wen Weng,Hao Ji,Elmurat Toreniyazov,Ximing Xu,Jiangnan Yu +11 more
TL;DR: ISL‐TPGS‐PLP could ameliorate the ISL solubility, bioavailability and liver targeting ability, suggesting that ISL'S‐modified proliposomes loaded with ISL could serve as a promising nanocarrier for liver cancer therapy.
Journal ArticleDOI
Vasculogenic mimicry, a complex and devious process favoring tumorigenesis - Interest in making it a therapeutic target.
TL;DR: In this article, the authors discuss the importance of VM-associated mediators in antitumor therapy and how it could allow to better understand the resistance to anticancer therapy and highlight the predominant molecular targets and signaling pathways involved.
References
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Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model
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Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica.
TL;DR: The results suggest that central and peripheral mechanism are involved in the pain modulation and anti-inflammation effects of brucine and Brucine N-oxide, biochemical mechanisms of bru cine and brucines N -oxide are different even though they are similar in chemical structure.
Journal ArticleDOI
The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism
Xu-Kun Deng,Wu Yin,Weidong Li,Fangzhou Yin,Xiaoyu Lu,Xiao-Chun Zhang,Zi-Chun Hua,Baochang Cai +7 more
TL;DR: It is indicated that the major alkaloids present in the seed of Strychnos nux-vomica are effective against HepG2 cells proliferation, among which brucine proceed HepG 2 cells death via apoptosis, probably through the participation of caspase-3 and cyclooxygenase-2.
Journal ArticleDOI
Potential of Liposomes for Enhancement of Oral Drug Absorption.
TL;DR: The present review focuses on the role of Liposomes in improving oral absorption of drugs, the problems encountered, and the types of liposomes designed to overcome these issues.
Journal ArticleDOI
Anti-tumor and anti-angiogenic effect of metronomic cyclic NGR-modified liposomes containing paclitaxel.
Li-Min Luo,Yue Huang,Bing-Xiang Zhao,Xin Zhao,Yu Duan,Ruo Du,Ke-Fu Yu,Ping Song,Yang Zhao,Xuan Zhang,Qiang Zhang +10 more
TL;DR: NGR-SSL-PTX is able to improve treatment efficacy producing the most significant anti-tumor activity and anti-angiogenic following metronomic administration.