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Journal ArticleDOI

Pharmaceutical evaluation of hydroxyalkyl ethers of β-cyclodextrins

Atsuya Yoshida, +3 more
- 01 Oct 1988 - 
- Vol. 46, Iss: 3, pp 217-222
TLDR
In this article, the physicochemical and biological properties and solubilizing abilities of 3-hexylated β-cyclodextrins (HA-β-CyDs), 2-hydroxypropyl β-Cyclodextrin (HP-βCyD), and Hydroxyethyl-β -Cyclodextrin (HE-β Cyclodexrin) were compared with those of parent β-cycle.
About: 
This article is published in International Journal of Pharmaceutics.The article was published on 1988-10-01. It has received 160 citations till now.

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Citations
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Journal ArticleDOI

Cyclodextrin Drug Carrier Systems.

Kaneto Uekama, +2 more
- 09 Jun 1998 - 
Journal ArticleDOI

Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery

Roger A. Rajewski, +1 more
- 01 Nov 1996 - 
TL;DR: This Review primarily focuses on newer findings concerning cyclodextrin derivatives which are likely to receive regulatory acceptance due to improved aqueous solubility and safety profiles as compared to the unmodified cyclodexypropyl-beta-cyclodextrins.
Journal ArticleDOI

Pharmaceutical applications of cyclodextrins. III. Toxicological issues and safety evaluation

Tetsumi Irie, +1 more
- 01 Feb 1997 - 
TL;DR: The objective of this review is to summarize recent findings on the safety profiles of three natural cyclodextrins (alpha, beta- and gamma-CDs) and several chemically modified CDs and their effects on cellular processes mediated by heparin binding growth factors.
Journal ArticleDOI

A review on cyclodextrin encapsulation of essential oils and volatiles

Helena Cabral Marques
- 01 Sep 2010 - 
TL;DR: In this article, a guest inclusion into the apolar CyD cavity is proved by various analytical techniques, including NMR spectroscopy, UV-visible absorption spectrography, optical rotatory dispersion and circular dichroism, fluorescence, infrared/FT-IR spectrographic, thermo-analysis, TLC, mass spectromety, and powder X-ray diffractometry.
Journal ArticleDOI

Cyclodextrin-based controlled drug release system.

Fumitoshi Hirayama, +1 more
- 01 Mar 1999 - 
TL;DR: In an oral drug delivery system (DDS), the hydrophilic and ionizable CDs can serve as potent drug carriers in the immediate release- and delayed release-formulations, respectively, while the release rate of water-soluble drugs can be retarded by hydrophobic CDs.
References
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Phase solubility techniques

T K Higuchi, +1 more
Book

Cyclodextrins and their inclusion complexes

Jozsef Szejtli
Journal Article

Cyclodextrins in drug carrier systems.

Uekama K, +1 more
- 01 Jan 1987 - 
TL;DR: The works published thus far apparently indicate that the inclusion phenomena of cyclodextrin analogs may allow the rational design of drug formulation and that the combination of molecular encapsulation with other carrier systems will become a very effective and valuable method for the development of a new drug delivery system in the near future.
Journal ArticleDOI

Hydroxypropyl-β-cyclodextrin: preparation and characterization; effects on solubility of drugs

Josef Pitha, +4 more
- 01 Mar 1986 - 
TL;DR: In this paper, conditions for condensation of β-cyclodextrin with propylene oxide were found which give preparations of hydroxypropyl-β-cyclodextrin with a narrow and symmetrical distribution of the degree of substitution.
Journal ArticleDOI

Amorphous Water-Soluble Derivatives of Cyclodextrins: Nontoxic Dissolution Enhancing Excipients

Josef Pitha, +1 more
- 01 Sep 1985 - 
TL;DR: Condensation products of cyclodextrins did not have any untoward or toxic effects when administered chronically to mice per os for a 16-week period.