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Pharmacogenomics of heart failure - focus on drug disposition and action
Arthur S. Leon,James S. Skinner,Jack H. Wilmore,D. C. Rao,Jacques Gagnon,Louis Pérusse,Yvon C. Chagnon,Treva Rice +7 more
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This article cites 44 articles, 23 of which you can access free at: http://ajpheart.org/cgi/content/full/279/1/H368#BIBL This article has been cited by 8 other HighWire hosted articles, the first 5 are:Abstract:
You might find this additional information useful... This article cites 44 articles, 23 of which you can access free at: http://ajpheart.physiology.org/cgi/content/full/279/1/H368#BIBL This article has been cited by 8 other HighWire hosted articles, the first 5 are: € [Abstract]€ [Full Text]€ [PDF] Physiol Genomics, August 14,€2002; 10€(2): 63-69. Douglass and J. M. Hagberg S. D. McCole, M. D. Brown, G. E. Moore, R. E. Ferrell, K. R. Wilund, A. Huberty, L. W.postmenopausal women Angiotensinogen M235T polymorphism associates with exercise hemodynamics in€ [Full Text]€ [PDF] Physiol Genomics, August 14,€2002; 10€(2): 45-47. L. A. Sonna, S. B. Glueck and X. Jeunemaitre M235T polymorphism associates with exercise hemodynamics in postmenopausal women" with reference to the angiotensinogen M235T polymorphism" and on "Angiotensinogen Exercise, genetics, and blood pressure: Focus on "Physical exercise and blood pressure€ [Abstract]€ [Full Text]€ [PDF] J Appl Physiol, February 1,€2004; 96€(2): 526-530. Huberty, L. W. Douglass and J. M. Hagberg S. D. McCole, A. R. Shuldiner, M. D. Brown, G. E. Moore, R. E. Ferrell, K. R. Wilund, A.postmenopausal women {beta}2- and {beta}3-Adrenergic receptor polymorphisms and exercise hemodynamics in€ [Abstract]€ [Full Text]€ [PDF] Cardiovasc Res, October 1,€2004; 64€(1): 32-39. I. Cascorbi, M. Paul and H. K. Kroemer Pharmacogenomics of heart failure - focus on drug disposition and action € [Full Text]€ [PDF] Diabetes Care, December 1,€2007; 30€(12): 3145-3151. Z. T. Bloomgarden Diabetes and Obesity: Part 1 on the following topics: Medline items on this article's topics can be found at http://highwire.stanford.edu/lists/artbytopic.dtl Medicine .. Exercise Medicine .. Genes Medicine .. Genetics Medicine .. Cardiovascular Genetics Medicine .. Fitness (Physical Activity) Physiology .. Exertion Updated information and services including high-resolution figures, can be found at: http://ajpheart.physiology.org/cgi/content/full/279/1/H368 Additional material and information about AJP - Heart and Circulatory Physiology can be found at: http://www.the-aps.org/publications/ajpheart This information is current as of February 25, 2010 . € ISSN: 0363-6135, ESSN: 1522-1539. Visit our website at http://www.the-aps.org/.read more
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Genetic Factors In Drug Metabolism
Donna J Belle,Harleen Singh +1 more
TL;DR: Although currently limited to a few pathways, pharmacogenetic testing may enable physicians to understand why patients react differently to various drugs and to make better decisions about therapy, and may shift the medical paradigm to highly individualized therapeutic regimens.
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Cardiovascular Ion Channel Inhibitor Drug-Drug Interactions with P-glycoprotein.
TL;DR: P-glycoprotein-mediated DDIs and their effects on pharmacokinetic predictions of cardiovascular therapeutics, for safer cardiovascular drug administration and for mitigating ADRs emanating from Pgp are discussed.
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MDR-1 C3435T polymorphism may affect blood pressure in resistant hypertensive patients independently of its effects on aldosterone release:
Riccardo Lacchini,Valeria N. Figueiredo,Caroline Demacq,Fernanda Borchers Coeli-Lacchini,Luís Cláudio Martins,Juan Carlos Yugar-Toledo,Antonio Coca,Jose E. Tanus-Santos,Heitor Moreno +8 more
TL;DR: The results show an association of C3435T with hypertension and with blood pressure levels in resistant hypertensive subjects, independent of aldosterone.
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Les enjeux de la translation des technologies : le cas des testsde pharmacogénétique au Québec
TL;DR: An exercise to provide a framework for thinking about the development of efficient translation mechanisms and the policies associated with it and to put into perspective the hopes being set forth regarding pharmacogenetics and the realistic nature of the enterprise.
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An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.
TL;DR: The insertion/deletion polymorphism accounted for 47% of the total phenotypic variance of serum ACE, showing that the ACE gene locus is the major locus that determines serum ACE concentration.
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Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction.
François Cambien,Odette Poirier,Laure Lecerf,Alun Evans,Jean-Pierre Cambou,Dominique Arveiler,Gérald Luc,Jean-Marie Bard,L Bara,Sylvain Ricard +9 more
TL;DR: It is reported that the DD genotype, which is associated with higher levels of circulating ACE than the ID and II genotypes, is significantly more frequent in patients with myocardial infarction than in controls, especially among subjects with low body-mass index and low plasma levels of ApoB.
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Molecular basis of human hypertension: Role of angiotensinogen
Xavier Jeunemaitre,Florent Soubrier,Yuri Kotelevtsev,Richard P. Lifton,Richard P. Lifton,Christopher S. Williams,Anne Charru,Steven C. Hunt,Paul N. Hopkins,Roger R. Williams,Jean Marc Lalouel,Pierre Corvol +11 more
TL;DR: Evidence of genetic linkage between the angiotensinogen gene (AGT) and hypertension is obtained, association of AGT molecular variants with the disease is demonstrated, and significant differences in plasma concentrations of angiotENSinogen among hypertensive subjects with different AGT genotypes are found.
Journal ArticleDOI
Triggering of acute myocardial infarction by heavy physical exertion. Protection against triggering by regular exertion. Determinants of Myocardial Infarction Onset Study Investigators
Murray A. Mittleman,Malcolm Maclure,Geoffrey H. Tofler,Jane B. Sherwood,Robert J. Goldberg,James E. Muller +5 more
TL;DR: Improved understanding of the mechanisms by which heavy physical exertion triggers the onset of myocardial infarction and the manner in which regular exertion protects against it would facilitate the design of new preventive approaches.
Journal Article
Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels.
Laurence Tiret,B Rigat,Sophie Visvikis,C Breda,Pierre Corvol,François Cambien,Florent Soubrier +6 more
TL;DR: A combined segregation and linkage analysis provided evidence that the major-gene effect was due to a variant of the ACE gene, in strong linkage disequilibrium with the I/D polymorphism.