Journal ArticleDOI
Phenotypic Diversity in Neuronal Cell Lines Derived from Raphe Nucleus by Retroviral Transduction
Reads0
Chats0
TLDR
Data are modeled to provide a conceptual framework as to the generation and differentiation capacity of neuronal cell lines derived by retroviral transduction and show both similar and different physiological properties.About:
This article is published in Methods.The article was published on 1995-06-01. It has received 17 citations till now. The article focuses on the topics: P19 cell & Neuroepithelial cell.read more
Citations
More filters
Journal ArticleDOI
The adult CNS retains the potential to direct region-specific differentiation of a transplanted neuronal precursor cell line
TL;DR: The results suggest that RN33B cells have the developmental plasticity to respond to local microenvironmental signals and that the adult brain retains the capacity to direct the differentiation of neuronal precursor cells in a direction that is consistent with that of endogenous neurons.
Journal ArticleDOI
Physiological relevance and functional potential of central nervous system-derived cell lines.
TL;DR: This article details recent progress in those cell lines that have enabled novel insight into the mechanisms controlling neuronal cell lineage choice and differentiation, both in vitro and in vivo.
Journal ArticleDOI
Development of fetal hippocampal grafts in intact and lesioned hippocampus.
Ashok K. Shetty,Dennis A. Turner +1 more
TL;DR: Recent developments in hippocampal transplants are summarized, especially the anatomical and/or functional integration of grafts within the host brain under specific host conditions, including a comparison of intact hippocampus with various types of hippocampal lesions or injury.
Journal ArticleDOI
Induction of mature neuronal properties in immortalized neuronal precursor cells following grafting into the neonatal CNS
TL;DR: Electro microscopy and immunohistochemistry data indicate that RN33B cells are capable of region-specific differentiation and have the potential to integrate functionally into the host CNS.
Journal ArticleDOI
Neuronal replacement strategies for spinal cord injury.
TL;DR: Results demonstrate that RN33B cells show remarkable plasticity to respond to local microenvironmental cues to differentiate in a direction that is morphologically indistinguishable from endogenous neurons at the site of transplantation, which should enable examination of the ability of these cells to restore function in the damaged CNS.