Journal ArticleDOI
Physical activity for patients undergoing an allogeneic hematopoietic stem cell transplantation: benefits of a moderate exercise intervention.
Freerk T. Baumann,Eva M. Zopf,Eike Nykamp,Ludwig Kraut,Klaus Schüle,Thomas Elter,Axel A. Fauser,Wilhelm Bloch +7 more
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TLDR
The results show that the training program is feasible and seems to have positive influences on physical performance and quality of life in patients undergoing an allogeneic HSCT, and further studies are necessary to confirm these results.Abstract:
An allogeneic hematopoietic stem cell transplantation (HSCT) can have profound and lasting adverse effects on a patient’s physical and psychological well-being. So far, only few studies have investigated the effectiveness of physical activity over the entire inpatient phase of an allogeneic HSCT. Purpose: We performed a randomized controlled study to examine the influence of a controlled moderate exercise program starting parallel to chemotherapeutic conditioning and total body irradiation on the patient’s physical and psychological constitution. Patients and methods: Forty-seven patients undergoing an allogeneic HSCT were randomly assigned to an exercise group (EG) or a control group (CG). While the EG took part in an endurance and activity of daily living-training twice a day, the CG received the clinic’s standard physiotherapy program once a day. Results: Significant differences and/or trends in favor of the EG were observed regarding the primary endpoint endurance performance (P = 0.002), muscular strength (P = 0.022), fatigue (P = 0.046), and emotional state (P = 0.028) without posing an additional risk for the individual. Conclusion: The results show that the training program is feasible and seems to have positive influences on physical performance and quality of life in patients undergoing an allogeneic HSCT. However, further studies are necessary to confirm these results.read more
Citations
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Exercise interventions on health related quality of life for people with cancer during active treatment
Shiraz I. Mishra,Roberta W. Scherer,Claire F. Snyder,Paula M Geigle,Debra R Berlanstein,Ozlem Topaloglu +5 more
TL;DR: The results suggest that exercise interventions compared with control interventions have a positive impact on overall HRZoL and certain HRQoL domains.
Journal ArticleDOI
Effect of exercise on cancer-related fatigue: a meta-analysis.
TL;DR: The results of this study suggest that exercise is effective for the management of cancer-related fatigue and has a moderate effect on reducing fatigue compared with control intervention.
Journal ArticleDOI
Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review
Guro Birgitte Stene,Jorunn L. Helbostad,Trude Rakel Balstad,Ingrid I. Riphagen,Stein Kaasa,Line Merete Oldervoll +5 more
TL;DR: It is demonstrated that aerobic and resistance exercise improves upper and lower body muscle strength more than usual care in cancer patients with advanced disease.
Journal ArticleDOI
Physical Exercise for Patients Undergoing Hematopoietic Stem Cell Transplantation: Systematic Review and Meta-Analyses of Randomized Controlled Trials
Inge E.P.M. van Haren,Hans Timmerman,C.M.J. Potting,Nicole M. A. Blijlevens,J. Bart Staal,Maria W.G. Nijhuis-van der Sanden +5 more
TL;DR: The results suggest that recipients of HSCT may benefit from physical exercise, with significant positive effects on QOL, fatigue, psychological well-being and distress, and physical functioning.
Journal ArticleDOI
Aerobic physical exercise for adult patients with haematological malignancies
Nils Bergenthal,Andrea Will,Fiona Streckmann,Klaus-Dieter Wolkewitz,Ina Monsef,Andreas Engert,Thomas Elter,Nicole Skoetz +7 more
TL;DR: Evaluating the efficacy, safety and feasibility of aerobic physical exercise for adults suffering from haematological malignancies concluded that there is moderate quality of evidence that exercise improves fatigue and that physical exercise improves quality of life.
References
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TL;DR: The understanding of the risk factors and causes of GHVD, the cellular and cytokine networks implicated in its pathophysiology, and current strategies to prevent and treat the disease are reviewed.
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Fernando C. Dimeo,Rolf-Dieter Stieglitz,Ulrike Novelli-Fischer,Sebastian Fetscher,Joseph Keul +4 more
TL;DR: It is proposed that physical activity training can reduce the intensity of fatigue in cancer patients undergoing chemotherapy and this group of patients.
Journal ArticleDOI
Effects of Aerobic Exercise on the Physical Performance and Incidence of Treatment-Related Complications After High-Dose Chemotherapy
TL;DR: It is concluded that aerobic exercise can be safely carried out immediately after high-dose chemotherapy and can partially prevent loss of physical performance in cancer patients undergoing chemotherapy.