Journal ArticleDOI
Phytosphingosine groups as quantitatively significant components of the sphingolipids of the mucosa of the small intestines of some mammalian species.
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TLDR
It is found that the lipid bases of the small intestines of fasted rats differed from those of other tissues by the presence of a fraction that moved more slowly than C18-dihydrosphingosine on thin-layer chromatograms in the solvent mixture of Sambasivarao and McCluer (1963).About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1968-04-05. It has received 61 citations till now. The article focuses on the topics: Ceramide & Sphingolipid.read more
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CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides.
Tetsu Kawano,Junqing Cui,Yasuhiko Koezuka,Isao Toura,Yoshikatsu Kaneko,Kazuhiro Motoki,Hitomi Ueno,Ryusuke Nakagawa,Hiroshi Sato,Eisuke Kondo,Haruhiko Koseki,Masaru Taniguchi +11 more
TL;DR: Glycosylceramide-mediated proliferative responses of Valpha14 NKT cells were abrogated by treatment with chloroquine-concanamycin A or by monoclonal antibodies against CD1d/Vbeta8, CD40/CD40L, or B7/CTLA-4/CD28, but not by interference with the function of a transporter-associated protein.
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Mammalian Lass6 and its related family members regulate synthesis of specific ceramides
TL;DR: The occurrence of N-glycosylation of some Lass proteins provides topological insight, indicating that the N-termini of Lass family members probably face the luminal side of the endoplasmic reticulum membrane, and topology for the conserved Lag1 motif in Lass members is proposed.
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Sphingolipid long chain bases
TL;DR: About 60 natural sphingolipid long chain bases have been identified or proposed and a review is given on their nomenclature, distribution, metabolism, biologic properties, chemistry and methods of characterization.
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Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.
TL;DR: Recent advances in understanding the functions of LCBP/S1P and C1P in mammals and in the yeast Saccharomyces cerevisiae are described.
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Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1
TL;DR: It is found that SPHK1 is a major sphingosine kinase in many tissues, especially in brain, heart, and colon, However, some tissues such as spleen, small intestine, and lung contained sphinga kinase activity that was not attributable to SP HK1 or SPHK2, as determined by immunodepletion assays.
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A simple method for the isolation and purification of total lipides from animal tissues.
TL;DR: In this paper, the authors described a simplified version of the method and reported the results of a study of its application to different tissues, including the efficiency of the washing procedure in terms of the removal from tissue lipides of some non-lipide substances of special biochemical interest.
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Qualitative microanalysis and estimation of sphingolipid bases
C.C. Sweeley,E.A. Moscatelli +1 more
TL;DR: A preliminary survey of various tissues is reported and the types of long-chain base found for each tissue are given and evidence is presented for the presence of a new long- chain base associatcd with the sphingomyelin fraction of human plasma lipids.
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Improved reagent for trimethylsilylation of sphingolipid bases
Herbert E. Carter,R.C. Gaver +1 more
TL;DR: The trimethylsilylation of sphingolipid bases under conditions that give derivatives of improved stability are described and retention times obtained on a commercially available gas-liquid chromatographic column with a nonpolar stationary phase are given.
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