Journal ArticleDOI
PI3K pathway inhibitors approach junction.
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TLDR
The PI3K–AKT–mTOR pathway has long been an attractive oncology target, but with top-line results from the most advanced AKT inhibitor due soon, many questions remain over which targets to hit and how to combine agents.Abstract:
The PI3K–AKT–mTOR pathway has long been an attractive oncology target. But with top-line results from the most advanced AKT inhibitor due soon, many questions remain over which targets to hit and how to combine agents.read more
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Journal ArticleDOI
Somatic overgrowth disorders of the PI3K/AKT/mTOR pathway & therapeutic strategies.
TL;DR: The clinical findings, gene function and pathogenesis of these mosaic overgrowth syndromes, and existing and future treatment strategies to reduce or prevent associated complications of these disorders are described.
Journal ArticleDOI
Nanotherapy for Cancer: Targeting and Multifunctionality in the Future of Cancer Therapies
TL;DR: The strategies for rationally designing nanoparticles for targeted, multimodal delivery of therapeutic agents and their potential for targeting and multifunctionality are reviewed.
Journal ArticleDOI
Somatic gain-of-function mutations in PIK3CA in patients with macrodactyly
Jonathan J. Rios,Nandina Paria,Dennis K. Burns,Bonnie A. Israel,Reuel Cornelia,Carol Wise,Marybeth Ezaki,Marybeth Ezaki +7 more
TL;DR: In this article, the authors used whole-exome sequencing to identify somatic mutations present in the affected nerve of a single patient, and confirmed a novel mutation in PIK3CA (R115P) present in a patient's affected nerve tissue but not in blood DNA.
Journal ArticleDOI
Midbrain and hindbrain malformations: advances in clinical diagnosis, imaging, and genetics
TL;DR: Research advances may change the way in which patients with developmental disorders of the midbrain and hindbrain are treated in the future and will enhance the clinical acumen of the practising neurologist and thereby improve the diagnosis and treatment of these patients.
Journal ArticleDOI
High Frequency of Activating PIK3CA Mutations in Human Papillomavirus–Positive Oropharyngeal Cancer
Anthony C. Nichols,David A. Palma,Winsion Chow,Susan Tan,Chandheeb Rajakumar,Giananthony Rizzo,Kevin Fung,Keith Kwan,B. Wehrli,Eric Winquist,James Koropatnick,Joe S. Mymryk,John Yoo,John W. Barrett +13 more
TL;DR: This is the first study to clearly identify the occurrence of activating PIK3CA mutations in HPV-positive HNSCC and suggest a mechanism to improve cure rates and decrease treatment toxic effects in this rapidly growing cohort of patients.
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