K
Kathleen J. Millen
Researcher at Seattle Children's Research Institute
Publications - 114
Citations - 7893
Kathleen J. Millen is an academic researcher from Seattle Children's Research Institute. The author has contributed to research in topics: Cerebellum & Granule cell. The author has an hindex of 43, co-authored 104 publications receiving 6843 citations. Previous affiliations of Kathleen J. Millen include Seattle Children's & Boston Children's Hospital.
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Journal ArticleDOI
Consensus Paper: Pathological Role of the Cerebellum in Autism
S. Hossein Fatemi,Kimberly A. Aldinger,Paul Ashwood,Margaret L. Bauman,Charles D. Blaha,Gene J. Blatt,Abha Chauhan,Ved Chauhan,Stephen R. Dager,Price E. Dickson,Annette Estes,Dan Goldowitz,Detlef H. Heck,Thomas L. Kemper,Bryan H. King,Loren A. Martin,Kathleen J. Millen,Guy Mittleman,Matthew W. Mosconi,Antonio M. Persico,John A. Sweeney,Sara Jane Webb,John P. Welsh +22 more
TL;DR: The diversity of opinions regarding the involvement of this important site in the pathology of autism will be observed, and points of consensus include presence of abnormal cerebellar anatomy, abnormal neurotransmitter systems, oxidative stress, Cerebellar motor and cognitive deficits, and neuroinflammation in subjects with autism.
Journal ArticleDOI
Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum.
TL;DR: The results show that En expression is a good marker for pattern formation in a variety of tissues and will be useful in experimental studies designed to characterize further these processes.
Journal ArticleDOI
Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants
TL;DR: Although cerebellar foliation is largely a postnatal process, the patterning of the cerebellum may begin during embryogenesis and that En-2 plays a critical role in this early process.
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Active medulloblastoma enhancers reveal subgroup-specific cellular origins
Charles Y. Lin,Charles Y. Lin,Serap Erkek,Yiai Tong,Linlin Yin,Alexander J. Federation,Marc Zapatka,Parthiv Haldipur,Daisuke Kawauchi,Thomas Risch,Hans-Jörg Warnatz,Barbara C. Worst,Bensheng Ju,Brent A. Orr,Rhamy Zeid,Donald R. Polaski,Maia Segura-Wang,Sebastian M. Waszak,David T.W. Jones,Marcel Kool,Volker Hovestadt,Ivo Buchhalter,Laura Sieber,Pascal Johann,Lukas Chavez,Stefan Gröschel,Marina Ryzhova,Andrey Korshunov,Andrey Korshunov,Wenbiao Chen,Victor V. Chizhikov,Kathleen J. Millen,Kathleen J. Millen,Vyacheslav Amstislavskiy,Hans Lehrach,Marie-Laure Yaspo,Roland Eils,Roland Eils,Peter Lichter,Jan O. Korbel,Stefan M. Pfister,Stefan M. Pfister,James E. Bradner,Paul A. Northcott +43 more
TL;DR: In this article, using H3K27ac and BRD4 chromatin immunoprecipitation followed by sequencing (ChIP-seq) coupled with tissue-matched DNA methylation and transcriptome data, the authors describe the active cis-regulatory landscape across 28 primary medulloblastoma specimens.
Journal ArticleDOI
Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice.
TL;DR: It is concluded that cell-specific differences in intracellular TH content due to differences in contribution of the various TH transporters are responsible for the unusual clinical presentation of this defect, in contrast to TH deficiency.