Journal ArticleDOI
Pituitary adrenal recovery following short-term suppression with corticosteroids.
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TLDR
It is suggested that brief courses of high-dose prednisone therapy may limit the adrenal component of the hypothalamic-pituitary-adrenal response to stress for up to five days.About:
This article is published in The American Journal of Medicine.The article was published on 1979-06-01. It has received 162 citations till now. The article focuses on the topics: Prednisone.read more
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Glucocorticoid Therapy for Immune-Mediated Diseases: Basic and Clinical Correlates
TL;DR: The molecular mechanisms, sites of action, and effects of glucocorticoids on various cells involved in inflammatory and immunologically mediated reactions are described and treatment principles are provided with examples of specific glucOCorticoid regimens in prototypical conditions.
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Corticosteroid therapy in severe illness
TL;DR: Standard therapy for the latter patients consists of the administration of high doses of corticosteroids during any severe illness and perioperatively, and replacement doses or high doses in patients with severe illness, especially those with multiorgan-system diseases.
Journal ArticleDOI
Multiple sclerosis in children: clinical diagnosis, therapeutic strategies, and future directions
TL;DR: Genetic and environmental factors, such as viral infection, might be uniquely amenable to study in paediatric patients with MS and their safe application in children can improve long-term prognosis.
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The effect of long-term glucocorticoid therapy on pituitary-adrenal responses to exogenous corticotropin-releasing hormone.
TL;DR: The degree of suppression of pituitary—adrenal function in patients treated with different doses of synthetic glucocorticoid medication for different periods is measured to determine the pituitaries response to the administration of exogenous human corticotropin-releasing hormone (CRH).
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Hypothalamic corticotropin-releasing hormone suppression during the postpartum period: implications for the increase in psychiatric manifestations at this time.
M A Magiakou,George Mastorakos,Douglas S. Rabin,Billinda Dubbert,Phillip W. Gold,George P. Chrousos +5 more
TL;DR: It is concluded that there is central suppression of hypothalamic CRH secretion in the postpartum, which might explain the increased vulnerability to the affective disorders observed during this period.
References
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Journal ArticleDOI
The determination of 17,21-dihydroxy-20-ketosteroids in urine and plasma.
Robert H. Silber,Curt C. Porter +1 more
TL;DR: Nelson and Samuels improved the procedure, primarily by employing chromatographic separation and micro cuvettes, so that they were able to measure the concentration of hydrocortisone in human plasma.
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A sensitive double antibody immunoassay for human growth hormone in plasma.
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Natural history of pituitary-adrenal recovery following long-term suppression with corticosteroids.
TL;DR: In this article, the authors measured plasma ACTH and 17-hydroxycorticosteroid concentrations at various intervals in patients recovering from prolonged pituitary suppression, and found a diurnal rhythm was observed in ACTH levels with a decrease to low values during the latter portion of each day.
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The plasma sugar, free fatty acid, cortisol, and growth hormone response to insulin. I. In control subjects.
F C Greenwood,J Landon,T C Stamp +2 more
TL;DR: A com-plex set of mechanisms normally operates to an-tagonize the action of insulin, thereby limiting the extent to which the blood glucose falls and causing a rapid return to original levels.