Journal ArticleDOI
Placental metabolism and its regulation in health and diabetes
Gernot Desoye,Eleazar Shafrir +1 more
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This article is published in Molecular Aspects of Medicine.The article was published on 1994-01-01. It has received 106 citations till now. The article focuses on the topics: Lipid metabolism & Carbohydrate metabolism.read more
Citations
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Journal ArticleDOI
Gestational diabetes mellitus.
H. David McIntyre,Patrick M. Catalano,Cuilin Zhang,Gernot Desoye,Elisabeth R. Mathiesen,Peter Damm +5 more
TL;DR: Gestational diabetes mellitus is the most common complication in pregnancy and has short-term and long-term effects in both mother and offspring, and dietary modification and increased physical activity are the primary treatments, but pharmacotherapy, usually insulin, is used when normoglycaemia is not achieved.
Journal ArticleDOI
Gestational Diabetes Induces Placental Genes for Chronic Stress and Inflammatory Pathways
TL;DR: It is reported that GDM elicits major changes in the expression profile of placental genes with a prominent increase in markers and mediators of inflammation, and placental transcriptome emerges as a primary target of the altered environment of diabetic pregnancy.
Journal ArticleDOI
The Role of Oxidative Stress in the Pathophysiology of Gestational Diabetes Mellitus
Martha Lappas,Martha Lappas,Ursula Hiden,Gernot Desoye,Julia Froehlich,Sylvie Hauguel-de Mouzon,Alicia Jawerbaum +6 more
TL;DR: This review provides an overview and updated data on the current understanding of the complications associated with oxidative changes in GDM and whether or not increased antioxidant intake can reduce the complications of GDM in both mother and fetus.
Journal ArticleDOI
The known and unknown of leptin in pregnancy
TL;DR: It is demonstrated that studies of leptin in pregnancy largely have contributed to insight into the mechanisms of leptin action, both as a hormone and as a cytokine.
Journal ArticleDOI
Triglyceride Hydrolase Activities and Expression of Fatty Acid Binding Proteins in the Human Placenta in Pregnancies Complicated by Intrauterine Growth Restriction and Diabetes
TL;DR: Results indicate that alterations in MVM LPL activity and expression of L-FABP may contribute to the altered lipid deposition and metabolism in IUGR and diabetic pregnancies.
References
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Journal ArticleDOI
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
Axel Ullrich,John Richard Bell,Ellson Y. Chen,R. Herrera,L. M. Petruzzelli,Thomas J. Dull,Alane M. Gray,Lisa M. Coussens,Yu Cheng Liao,M. Tsubokawa,Anthony J. Mason,Peter H. Seeburg,C. Grunfeld,Ora M. Rosen,J. Ramachandran,J. Ramachandran +15 more
TL;DR: The entire 1,370-amino-acid sequence of the human insulin receptor precursor is deduced from a single complementary DNA clone, finding sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.
Book
Pathology of the human placenta
Kurt Benirschke,Peter Kaufmann +1 more
TL;DR: Early development of the human placenta and histopathologic approach to villous alterations are studied.
Journal ArticleDOI
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein.
Xiao Jian Sun,P. Rothenberg,P. Rothenberg,C R Kahn,Jonathan M. Backer,E. Araki,P. A. Wilden,D. A. Cahill,Barry J. Goldstein,Morris F. White +9 more
TL;DR: During insulin stimulation, the IRS-1 protein undergoes tyrosine phosphorylation and binds phosphatidylinositol 3-kinase, suggesting that IRS–1 acts as a multisite Mocking' protein to bind signal-transducing molecules containing Src-homology 2 and SRC-Homology-3 domains, which may link the insulin receptor kinase and enzymes regulating cellular growth and metabolism.
Journal ArticleDOI
Purification, Characterization, and in vitro Differentiation of Cytotrophoblasts from Human Term Placentae*
TL;DR: It is concluded that human cytotrophoblasts differentiate in culture and fuse to form functional syncytiotrophobic cells, similar to that of intact term placentae.
Journal ArticleDOI
The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling
Yousuke Ebina,Leland Ellis,Kurt Jarnagin,Marc Edery,László Gráf,Eric Clauser,Jing-Hsiung Ou,Frank Masiarz,Yuet Wai Kan,Ira D. Goldfine,Richard A. Roth,William J. Rutter +11 more
TL;DR: A cloned approximately 5 kb cDNA (human placenta) contains the coding sequences for the insulin receptor; the nucleotide sequence predicts a 1382 amino acid precursor and the overall structure is reminiscent of the EGF receptor.